Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 44: 2347-2352, 1998;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kazmierczak, S. C.
Right arrow Articles by Boudreau, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kazmierczak, S. C.
Right arrow Articles by Boudreau, D.
Related Collections
Right arrow Laboratory Management
(Clinical Chemistry. 1998;44:2347-2352.)
© 1998 American Association for Clinical Chemistry, Inc.

Laboratory Management

Simplified interpretative format for assessing test interference: studies with hemoglobin-based oxygen carrier solutions

Steven C. Kazmierczak1,a, Paul G. Catrou1, and Donald Boudreau2

1 Department of Pathology and Laboratory Medicine, East Carolina University School of Medicine, Brody 7S-19, Greenville, NC 27858-4354.

2 Department of Pathology and Laboratory Medicine, Louisiana State University Medical Center, Box P51, 1901 Perdido Street, New Orleans, LA 70112-1328.
a Author for correspondence. Fax 252-816-8200; e-mail kaz{at}brody.med.ecu.edu.

Substances such as hemoglobin that interfere with analytical processes are recognized as a frequent source of error in laboratory medicine. Standard guidelines for assessment of test interferences assume that interference effects are not related to the concentration of the analyte being measured. However, previous investigations have demonstrated that interference effects can be markedly different, depending on the concentrations of interferent and analyte within the specimen. An experimental protocol for investigating these different types of interference effects has been developed. This protocol utilizes an orthogonally arranged matrix with progressively increasing concentrations of analyte and interferent. Evaluation of the measured analyte concentrations in specimens within the matrix using multiple regression analysis allows the magnitude, direction, and significance of each type of interference to be determined. Unfortunately, implementation of the interference data derived from the multiple regression analysis for judging the clinical acceptability of test results when an interferent is present is difficult. We describe a two-dimensional graphical format for evaluating the clinical acceptability of test results, based on criteria established under the Clinical Laboratory Improvement Amendments of 1988, in specimens containing hemoglobin-based oxygen carrier solutions.




The following articles in journals at HighWire Press have cited this article:


Home page
 Anesth. Analg.Home page
A. A. Ali, G. S. Ali, J. M. Steinke, and A. P. Shepherd
Co-Oximetry Interference by Hemoglobin-Based Blood Substitutes
Anesth. Analg., April 1, 2001; 92(4): 863 - 869.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
J. J. Chance, E. J. Norris, and M. H. Kroll
Mechanism of Interference of a Polymerized Hemoglobin Blood Substitute in an Alkaline Phosphatase Method
Clin. Chem., September 1, 2000; 46(9): 1331 - 1337.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Association for Clinical Chemistry.