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Enzymes and Protein Markers |
1
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia.
2
The Queensland Institute of Medical Research, Brisbane
4029, Australia.
3
Department of Psychiatry, Washington University School
of Medicine, St. Louis, MO 63130.
a Author for correspondence. Fax 61 2 9515 7931; e-mail johnwhit{at}bioc.rpa.cs.nsw.gov.au.
Serum carbohydrate-deficient transferrin (CDT) is a specific and comparatively sensitive marker of excessive alcohol use; however, reports of its sensitivity vary according to the population or patient groups studied and their average alcohol intake. We have characterized the dose–response curve between alcohol intake and CDT concentrations in a study of 1400 men and women from a community-based twin registry. Our results show that mean CDT increases with increasing reported alcohol consumption even within the range of alcohol use considered to be nonhazardous. We found significant effects of sex, age, smoking, previous alcohol dependence, body mass index, and diastolic hypertension on the alcohol-CDT dose–response curve. These variables either affect test sensitivity or require adjustment of reference intervals. The results also provide insight into the physiological and biochemical factors that affect CDT concentration.
The following articles in journals at HighWire Press have cited this article:
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  D. T. O'Connor, G. Zhu, F. Rao, L. Taupenot, M. M. Fung, M. Das, S. K. Mahata, M. Mahata, L. Wang, K. Zhang, et al. Heritability and Genome-Wide Linkage in US and Australian Twins Identify Novel Genomic Regions Controlling Chromogranin A: Implications for Secretion and Blood Pressure Circulation, July 15, 2008; 118(3): 247 - 257. [Abstract] [Full Text] [PDF]
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A. Valle, D. T. O'Connor, P. Taylor, G. Zhu, G. W. Montgomery, P. E. Slagboom, N. G. Martin, and J. B. Whitfield Butyrylcholinesterase: Association with the Metabolic Syndrome and Identification of 2 Gene Loci Affecting Activity Clin. Chem., June 1, 2006; 52(6): 1014 - 1020. [Abstract] [Full Text] [PDF]
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B. M.R. Appenzeller and R. Wennig Altered Distribution of Transferrin Isoforms According to Serum Storage Conditions Clin. Chem., November 1, 2005; 51(11): 2159 - 2162. [Full Text] [PDF]
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A. Van Campenhout, C. Van Campenhout, A. R. Lagrou, and B. Manuel-y-Keenoy Effects of in Vitro Glycation on Fe3+ Binding and Fe3+ Isoforms of Transferrin Clin. Chem., September 1, 2004; 50(9): 1640 - 1649. [Abstract] [Full Text] [PDF]
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 M. Fleming and M. Mundt Carbohydrate-Deficient Transferrin: Validity of a New Alcohol Biomarker in a Sample of Patients with Diabetes and Hypertension J Am Board Fam Med, July 1, 2004; 17(4): 247 - 255. [Abstract] [Full Text] [PDF]
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J. B. Whitfield Transferrin Isoform Analysis for the Diagnosis and Management of Hazardous or Dependent Drinking Clin. Chem., December 1, 2002; 48(12): 2095 - 2096. [Full Text] [PDF]
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J. B. Whitfield, G. Zhu, J. E. Nestler, A. C. Heath, and N. G. Martin Genetic Covariation between Serum {gamma}-Glutamyltransferase Activity and Cardiovascular Risk Factors Clin. Chem., September 1, 2002; 48(9): 1426 - 1431. [Abstract] [Full Text] [PDF]
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A. Reif, H. Keller, M. Schneider, S. Kamolz, A. Schmidtke, and A. J. Fallgatter CARBOHYDRATE-DEFICIENT TRANSFERRIN IS ELEVATED IN CATABOLIC FEMALE PATIENTS Alcohol Alcohol., November 1, 2001; 36(6): 603 - 607. [Abstract] [Full Text] [PDF]
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T. Arndt Carbohydrate-deficient Transferrin as a Marker of Chronic Alcohol Abuse: A Critical Review of Preanalysis, Analysis, and Interpretation Clin. Chem., January 1, 2001; 47(1): 13 - 27. [Abstract] [Full Text] [PDF]
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 G. Brathen, K. S Bjerve, E. Brodtkorb, and G. Bovim Validity of carbohydrate deficient transferrin and other markers as diagnostic aids in the detection of alcohol related seizures J. Neurol. Neurosurg. Psychiatry, March 1, 2000; 68(3): 342 - 348. [Abstract] [Full Text] [PDF]
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