Clinical Chemistry
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Clinical Chemistry 44: 239-243, 1998;
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(Clinical Chemistry. 1998;44:239-243.)
© 1998 American Association for Clinical Chemistry, Inc.

Endocrinology and Metabolism

Direct enzyme immunometric measurement of plasma big endothelin-1 concentrations and correlation with indicators of left ventricular function

Cornelia Haug1,a, Wolfgang Koenig2, Martin Hoeher2, Matthias Kochs2, Vinzenz Hombach2, Adolf Gruenert1, and Hans Osterhues2

1 Institute of Clinical Chemistry,
2 Department of Internal Medicine II, University Hospital, Ulm, Germany.
a Address correspondence to this author at: Institute of Clinical Chemistry, University Hospital Ulm, Robert-Koch-Str. 8, D-89070 Ulm, Germany. Fax 0731-5024584; e-mail cornelia.haug{at}medizin.uni-ulm.de.

Recent studies have suggested that the plasma concentrations of endothelin-1, a potent vasoconstrictive peptide, are increased in patients with congestive heart failure. This study aimed to evaluate a new direct ELISA for big endothelin-1 (the precursor of endothelin-1), in comparison with a big endothelin-1 ELISA using plasma sample extraction, and to investigate whether plasma big endothelin-1 concentrations correlate with indicators of left ventricular function. The direct ELISA yielded significantly (P <0.001) lower results than the assay with extracted samples (0.9 ± 0.5 pmol/L vs 2.7 ± 1.9 pmol/L; n = 90); however, the results of the two assays were closely correlated (r = 0.86, P <0.001). Plasma big endothelin-1 concentrations exhibited a significant (P <0.001) negative correlation (r = -0.46, r = -0.40) with the left ventricular ejection fraction and a significant positive correlation (r = 0.40, P <0.001; r = 0.36, P <0.01) with the left ventricular end-diastolic pressure and the left ventricular end-diastolic (r = 0.42, r = 0.38, P <0.001) and end-systolic (r = 0.52, r = 0.47, P <0.001) volume indices. Plasma big endothelin-1 concentrations were notably greater in patients with New York Heart Association (NYHA) class II–IV symptoms than in patients without cardiac disease or in patients categorized to NYHA class I. These data suggest that plasma big endothelin-1 concentrations, measured by a direct ELISA, correlate with hemodynamic indicators and symptoms of left ventricular dysfunction.




The following articles in journals at HighWire Press have cited this article:


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Decrease in plasma B-type natriuretic peptide early after initiation of cardiac resynchronization therapy predicts clinical improvement at 12 months
Eur J Heart Fail, December 1, 2006; 8(8): 832 - 840.
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M. Kubanek, I. Malek, J. Kautzner, M. Hegarova, M. Wiendl, P. Lupinek, L. Karasova, and V. Lanska
The value of B-type natriuretic peptide and big endothelin-1 for detection of severe pulmonary hypertension in heart transplant candidates
Eur J Heart Fail, December 1, 2005; 7(7): 1149 - 1155.
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D. Lepailleur-Enouf, G. Egidy, M. Philippe, L. Louedec, J.-P. Henry, P. Mulder, and J.-B. Michel
Pulmonary endothelinergic system in experimental congestive heart failure
Cardiovasc Res, February 1, 2001; 49(2): 330 - 339.
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