Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 44: 275-280, 1998;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smith, R. F.
Right arrow Articles by Ellard, G. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, R. F.
Right arrow Articles by Ellard, G. A.
Related Collections
Right arrow Evidence Based Laboratory Medicine and Test Utilization
Right arrow Drug Monitoring and Toxicology
(Clinical Chemistry. 1998;44:275-280.)
© 1998 American Association for Clinical Chemistry, Inc.

Drug Monitoring and Toxicology

Assessment of simple colorimetric procedures to determine smoking status of diabetic subjects

Robert F. Smith1,a, Hugh M. Mather2, and Gordon A. Ellard3

1 Division of Biomedical Sciences, School of Science, Sheffield Hallam University, Pond St., Sheffield S1 1WB, UK.

2 Ealing Hospital, Uxbridge Rd., Southall Middlesex UB1 3HW, UK.

3 Department of Medical Microbiology, St. George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.
a Author for correspondence. Fax 114 2533066 e-mail r.f.smith{at}shu.ac.uk.

The performance of a simple colorimetric assay for urinary nicotine metabolites to assess smoking status in diabetic subjects (n = 251) was investigated. Several variations of the colorimetric assay and a qualitative extraction procedure were evaluated in comparison with a cotinine immunoassay as the "gold standard." Among these, the best overall performance was achieved with the qualitative test (sensitivity 95%; specificity 100%). The quantitative measurement of total nicotine metabolites performed less well (sensitivity 92%; specificity 97%) but could be improved by incorporating a blank extraction (sensitivity 98%; specificity 98%). Allowance for diuresis appeared to offer no advantage over the other methods. These results support previous findings regarding the use of these colorimetric procedures in nondiabetic subjects and, contrary to other recent observations, their performance was not impaired in diabetic patients.




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
G. F. Cope
Simple Colorimetric Procedures to Determine Smoking Status
Clin. Chem., April 1, 1999; 45(4): 585 - 585.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Association for Clinical Chemistry.