Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 44: 293-298, 1998;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schrier, W. H.
Right arrow Articles by Chandler, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schrier, W. H.
Right arrow Articles by Chandler, H.
Related Collections
Right arrow Clinical Immunology
Right arrow Automation and Analytical Techniques
(Clinical Chemistry. 1998;44:293-298.)
© 1998 American Association for Clinical Chemistry, Inc.

Immunology

Development of FlexSure® HP—an immunochromatographic method to detect antibodies against Helicobacter pylori

Wayne H. Schrier, Ronald J. Schoengolda, Josefina T. Baker, Joyce L. Norell, Corey L. Jaseph, Yelena Okin, Jeam Y. Doe, and Howard Chandler1

1 176A Princess Point Rd., Yarmouth, ME 04103.
a Author for correspondence. Fax 415-845-3540;

We describe a solid-phase immunochromatographic serologic test, FlexSure® HP, to detect IgG antibodies against Helicobacter pylori. H. pylori colonize the stomach and proximal duodenum, cause ulcer disease and mucosa-associated lymphoid tissue lymphoma, and have a role in the development of other disorders, including gastric adenocarcinoma. FlexSure HP consists of a test strip, conjugate pad, and absorbent pad, in a novel reverse-flow chromatography format. In these studies, FlexSure HP was demonstrated to be specific for IgG antibodies against H. pylori. The reactive cutoff of the test was consistent with [13C]urea breath test and commercially available ELISAs. FlexSure HP had 94% sensitivity, 88% specificity, and 91% accuracy relative to [13C]urea breath test; and 95% sensitivity, 94% specificity, and 95% overall agreement relative to high-molecular-mass cell-associated protein enzyme immunoassay (HM-CAP EIA). FlexSure HP is a simple-to-perform, visually read test requiring no specialized training, equipment, or instrumentation, and yields rapid, accurate, qualitative results.




The following articles in journals at HighWire Press have cited this article:


Home page
 CVIHome page
A. H. Peruski and L. F. Peruski Jr.
Immunological Methods for Detection and Identification of Infectious Disease and Biological Warfare Agents
Clin. Vaccine Immunol., July 1, 2003; 10(4): 506 - 513.
[Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
W. K. Leung, F. K. L. Chan, M. S. Falk, R. Suen, and J. J. Y. Sung
Comparison of Two Rapid Whole-Blood Tests for Helicobacter pylori Infection in Chinese Patients
J. Clin. Microbiol., November 1, 1998; 36(11): 3441 - 3442.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Association for Clinical Chemistry.