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Clinical Chemistry 44: 370-374, 1998;
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(Clinical Chemistry. 1998;44:370-374.)
© 1998 American Association for Clinical Chemistry, Inc.


TDM Conference

Total testing process applied to therapeutic drug monitoring: impact on patients' outcomes and economics

Gerald E. Schumachera, and Judith T. Barr

a Author for correspondence. Fax 617-373-2968,


Abstract

The Total Testing Process (TTP) refers to the sequence of 11 steps of laboratory testing, beginning with a clinical question prompted by the patient–clinician encounter and concluding with the impact of the test result on patient care. TTP when applied to therapeutic drug monitoring (TDM) emphasizes that TDM must be considered a process involving a series of steps and interrelated activities and not viewed simply as a numerical value for a serum drug concentration. TTP is also an ideal format for organizing and identifying the system-related and patient-centered variables used in outcomes assessment of TDM, as well as providing a template for collecting the cost data needed for economic analyses. Examples are provided for improving application of TDM by practitioners, clinical laboratories, and educators.




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