Clinical Chemistry
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Clinical Chemistry 44: 375-380, 1998;
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(Clinical Chemistry. 1998;44:375-380.)
© 1998 American Association for Clinical Chemistry, Inc.

TDM Conference

Analytical goals in therapeutic drug monitoring

Larry D. Bowers

Department of Pathology and Laboratory Medicine, Indiana University Medical Center, 635 Barnhill Dr., Indianapolis, IN 46202-5120. Fax 317-274-3223; e-mail lbowers{at}iupui.edu.


Abstract

The practice of therapeutic drug monitoring is based on several disciplines, including pharmacokinetics, pharmacodynamics, and chemical analysis. The impact of the analysis on the determination of pharmacokinetic parameters is not well appreciated. Analytical goals in therapeutic drug monitoring should be established by determining the nature of the problem to be solved, selecting the appropriate matrix and methodology to solve the problem, and developing valid analytical schemes that are performed competently with appropriate quality and interpreted within the framework of the problem.




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[Abstract] [Full Text] [PDF]


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