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Clinical Chemistry 44: 517-521, 1998;
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(Clinical Chemistry. 1998;44:517-521.)
© 1998 American Association for Clinical Chemistry, Inc.

Lipids and Lipoproteins

Plasma lipoprotein profiles change significantly during cardiac catheterization

Takashi Miida1,a, Hideaki Otsuka2, Atsushi Tsuchiya2, and Masahiko Okada1

1 Department of Laboratory Medicine, Niigata University School of Medicine, Asahimachi 1–757, Niigata, Niigata 951–8510, Japan.

2 Department of Cardiology, Niigata Kobari Hospital, Kobari 3-27-11, Niigata, Niigata 950–2022, Japan.
a Author for correspondence. Fax +81-223-0996; e-mail miida{at}med.niigata-u.ac.jp.

Most patients in acute myocardial infarction (AMI) undergo emergent coronary angiography (CAG). However, when to analyze lipoprotein profiles in AMI is not clear. To determine whether lipoprotein profiles change during catheterization, we measured serum lipid and apolipoprotein concentrations in 65 patients (51 men and 14 women) before and after catheterization. Heparin was injected at 50 units/kg for CAG and 200 units/kg for percutaneous transluminal coronary angioplasty (PTCA). We found that cholesterol and triglyceride decreased by 9.4% (P <0.001) and 53.1% (P <0.001), respectively, after catheterization. Apolipoproteins also decreased significantly. Variables decreased two to five times more after PTCA than after CAG. Lipoprotein lipase mass was higher after PTCA (267.8 ± 135.3 µg/L) than after CAG (93.3 ± 48.4 µg/L; P <0.05). In conclusion, lipoprotein profiles change during catheterization. We recommend avoiding analysis of lipoprotein profiles after emergent CAG in AMI.






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Copyright © 1998 by the American Association for Clinical Chemistry.