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Clinical Chemistry 44: 800-804, 1998;
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(Clinical Chemistry. 1998;44:800-804.)
© 1998 American Association for Clinical Chemistry, Inc.

Hematology

Zinc protoporphyrin as screening test in female blood donors

Else J. Harthoorn-Lasthuizen1,a, Jan Lindemans2, and Mart M. A. C. Langenhuijsen3

1 Laboratory of Hematology, Bosch Medicentrum, 5211 NL 's-Hertogenbosch, The Netherlands.

2 Department of Clinical Chemistry, Akademisch Ziekenhuis Rotterdam, 3000 CA Rotterdam, The Netherlands.

3 Department of Hematology, Vrije Universiteit Amsterdam, 1007 MB Amsterdam, The Netherlands.
a Address correspondence to this author at: Laboratory of Hematology, Bosch Medicentrum, Nieuwstraat 34 5211 NL 's-Hertogenbosch, The Netherlands. Fax 31-736162958; e-mail JLHART.EJLAST{at}inter.NL.net.

Erythrocyte zinc protoporphyrin (ZPP) was measured in 102 women blood donors to evaluate its usefulness in screening for evolving iron deficiency anemia, a reason for the deferral of donors. The results were compared with serum ferritin determinations. Five women were deferred before their first donation and eight women were deferred after one or two donations. Women with increased ZPP values all had low serum ferritin concentrations, indicating iron-deficient erythropoiesis that was caused by iron depletion. The positive predictive value of an increased ZPP in predicting deferral of the donor after one or two donations was 75%, whereas a serum ferritin concentration <=12 µg/L predicted deferral in 26% of the donors. The results indicate that the ZPP test can be recommended as a feasible and inexpensive predonation test to determine a subset of donors with iron-deficient erythropoiesis at risk of developing iron deficiency anemia.




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
R. F. Labbe, H. J. Vreman, and D. K. Stevenson
Zinc Protoporphyrin: A Metabolite with a Mission
Clin. Chem., December 1, 1999; 45(12): 2060 - 2072.
[Abstract] [Full Text] [PDF]


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Copyright © 1998 by the American Association for Clinical Chemistry.