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Clinical Chemistry 44: 1073-1084, 1998;
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(Clinical Chemistry. 1998;44:1073-1084.)
© 1998 American Association for Clinical Chemistry, Inc.

NACB Symposium

Standards of laboratory practice: antidepressant drug monitoring

Mark W. Linder1,a, and Paul E. Keck, Jr.2

1 Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY 40292.

2 Biological Psychiatry Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45221.
a Author for correspondence. Fax 502-852-8299; e-mail mwlind01{at}homer.louisville.edu.

Therapeutic drug monitoring (TDM) for certain tricyclic antidepressants (TCAs) and lithium is supported on the basis of clearly defined therapeutic ranges. TDM is of particular importance in individuals whose pharmacokinetic behavior may differ from that of the general population or is changing as the result of aging and maturation. Once steady-state drug concentrations are achieved, serum or plasma specimens should be collected during the terminal drug-elimination phase and separated from cellular blood components immediately. Methods of analysis must be specific for parent drug and active metabolites and demonstrate imprecision (CVs) within 5–10% over the therapeutic range. For support of overdose situations, semiquantitative values for TCAs and quantitative measures of lithium should be available within 1 h, and routine TDM results should be reported within 24 h of receipt in the laboratory. Standardized and rigorous laboratory practices contribute to improved therapeutic management.




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