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Clinical Chemistry 44: 1251-1255, 1998;
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Right arrow Drug Monitoring and Toxicology
(Clinical Chemistry. 1998;44:1251-1255.)
© 1998 American Association for Clinical Chemistry, Inc.

Drug Monitoring and Toxicology

Determination of ciprofloxacin in plasma and urine by HPLC with ultraviolet detection

Marika Kamberia, Kimiko Tsutsumi, Tsutomu Kotegawa, Koichi Nakamura, and Shigeyuki Nakano

Department of Clinical Pharmacology and Therapeutics, Oita Medical University, Oita 879-55, Japan.
a Address correspondence to this author at: Department of Clinical Pharmacology and Therapeutics, Oita Medical University, 1-1, Hasama-machi, Oita 879-55, Japan. Fax 81-975-49-6044.

A simple, sensitive isocratic method for the detection and quantification of ciprofloxacin in plasma and urine has been developed. The assay consisted of reversed-phase HPLC with ultraviolet detection. Plasma proteins were removed by a fast and efficient procedure. For the urine samples, the only required sample preparation was dilution. Separation was achieved on a C18 reversed-phase column. The quantification limit was 0.01 mg/L in plasma and 0.5 mg/L in urine. This method was sufficiently sensitive for pharmacokinetic studies.




The following articles in journals at HighWire Press have cited this article:


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M. Kamberi, K. Tsutsumi, T. Kotegawa, K. Kawano, K. Nakamura, Y. Niki, and S. Nakano
Influences of Urinary pH on Ciprofloxacin Pharmacokinetics in Humans and Antimicrobial Activity In Vitro versus Those of Sparfloxacin
Antimicrob. Agents Chemother., March 1, 1999; 43(3): 525 - 529.
[Abstract] [Full Text]


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