Clinical Chemistry
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Clinical Chemistry 44: 1256-1261, 1998;
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(Clinical Chemistry. 1998;44:1256-1261.)
© 1998 American Association for Clinical Chemistry, Inc.

Drug Monitoring and Toxicology

Paraquat-induced renal injury studied by 1H nuclear magnetic resonance spectroscopy of urine

Eleni Bairaktari1,a, Kostas Katopodis2, Kostas C. Siamopoulos2, and Orestes Tsolas1

1 Laboratory of Biochemistry (University Hospital) and
2 Department of Nephrology, University of Ioannina Medical School, GR 455 00 Ioannina, Greece.
a Address correspondence to this author at: Laboratory of Biochemistry, Regional University General Hospital of Ioannina, GR-455 00 Ioannina, Greece. Fax 30-651-99418; e-mail ebairakt{at}cc.uoi.gr.

The herbicide paraquat (1,1'-dimethyl-4,4'-bipyridylium dichloride; PQ), is a poison known to cause delayed mortality due to lung and kidney injuries. High-resolution proton nuclear magnetic resonance (1H NMR) spectroscopy has been extensively applied in evaluating nephrotoxicity by the characteristic perturbations in the excretion pattern of low molecular weight endogenous metabolites. The application of the method allows the rapid localization of the renal injury noninvasively. In this study, we report 1H NMR and conventional clinical chemistry urinalysis in two patients suffering from paraquat intoxication after overdose with suicidal intent. The alterations in the urine NMR spectrum suggest necrosis of the pars recta of the proximal renal tubules. The molecule of paraquat is also clearly detected in the same spectrum. In conclusion, the rapid screening of urine by NMR spectroscopy provides information about both the identity of the poison and the abnormal pattern of endogenous metabolites that characterize the location of the injury in renal tubules and reveals alterations in unusual metabolites that are not commonly measured.




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