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Clinical Chemistry 44: 1466-1473, 1998;
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(Clinical Chemistry. 1998;44:1466-1473.)
© 1998 American Association for Clinical Chemistry, Inc.

Lipids and Lipoproteins

Human cholesteryl ester transfer protein measured by enzyme-linked immunosorbent assay with two monoclonal antibodies against rabbit cholesteryl ester transfer protein: plasma cholesteryl ester transfer protein and lipoproteins among Japanese hypercholesterolemic patients

Kanna Sasai1,2, Kuniko Okumura-Noji1, Takeshi Hibino2, Reiko Ikeuchi2, Nagahiko Sakuma2, Takao Fujinami2, and Shinji Yokoyama1,a

Departments of
1 Biochemistry I and
2 Internal Medicine III, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
a Author for correspondence. Fax 81-52-841-3480; e-mail syokoyam{at}med.nagoya-cu.ac.jp.

Plasma cholesteryl ester transfer protein (CETP) concentrations were measured in Japanese subjects by an ELISA with two different monoclonal antibodies that were raised against rabbit CETP and cross-reacted against human CETP. Among 63 patients who consecutively underwent coronary angiography, the plasma CETP of 37 patients with luminal stenosis >=50% in their coronary arteries was not significantly different from that of the 26 patients with luminal stenosis <50%. No other lipoprotein-related measurement except HDL-cholesterol differentiated the two groups. Among 40 hypercholesterolemic patients, no lipoprotein-related measurement other than LDL-cholesterol was found to positive correlate with the CETP. Before and after the treatment of 23 patients with simvastatin 5 mg a day for 4 weeks, plasma CETP markedly decreased in those whose pretreatment CETP was >=3 mg/L; no change was observed for those with lower pretreatment CETP. In the former group, negative correlation between CETP and HDL-cholesterol was demonstrated only in the posttreatment plasma.




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