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Clinical Chemistry 44: 1529-1534, 1998;
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(Clinical Chemistry. 1998;44:1529-1534.)
© 1998 American Association for Clinical Chemistry, Inc.

Automation and Analytical Techniques

Proton nuclear magnetic resonance spectral profiles of urine in type II diabetic patients

Irene Messana, Franca Forni, Franco Ferrari, Cristina Rossi, Bruno Giardina, and Cecilia Zuppia

a Address correspondence to this author at: Istituto di Chimica e Chimica Clinica, Università Cattolica del Sacro Cuore, Largo F.Vito 1–00168 Rome, Italy. Fax 039-6-30501918.

Serial urine samples of 33 type II diabetic patients and 20 control subjects were examined by 1H nuclear magnetic resonance (NMR). Metabolites including lactate, citrate, glycine, alanine, hippurate, trimethylamine-N-oxide, and dimethylamine were identified in all subjects although in higher concentrations in diabetic patients. Other analytes, such as creatine, acetate, betaine, and ketone bodies, were found more frequently and in greater concentrations in diabetics than in controls. In addition, although lactate, citrate, alanine, and hippurate concentrations increased with increasing glycosuria and glycohemoglobin, trimethylamine-N-oxide and dimethylamine were present at high concentrations even in diabetics with good metabolic control. 1H NMR spectroscopy permitted us to explore the relationships among the metabolites present in the urine samples and to obtain information about the disease status in type II diabetic patients.




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