Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 44: 1833-1843, 1998;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (183)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jacobsen, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jacobsen, D. W.
Related Collections
Right arrow Arnold O. Beckman Conference
Right arrow Proteomics and Protein Markers
Right arrow Lipids, Lipoproteins, and Cardiovascular Risk Factors
Right arrow Endocrinology and Metabolism
(Clinical Chemistry. 1998;44:1833-1843.)
© 1998 American Association for Clinical Chemistry, Inc.

Proceedings of the 21st Arnold O. Beckman Conference

Homocysteine and vitamins in cardiovascular disease

Donald W. Jacobsena

Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, and Department of Chemistry, Cleveland State University, Cleveland, OH 44115.
a Address for correspondence. Department of Cell Biology, FF4-07, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195. Fax 216-445-5480; e-mail jacobsd{at}cesmtp.ccf.org.


Abstract

On the basis of recent retrospective and prospective studies, it is now widely accepted that increased total plasma homocysteine is a risk factor for cardiovascular disease. Impaired enzyme function as a result of genetic mutation or deficiency of the essential B vitamins folic acid, B12, and B6 can lead to hyperhomocysteinemia. Oxidized forms of homocysteine account for 98–99% of total plasma homocysteine. Although there is uncertainty as to whether increased homocysteine is causal or merely a proxy for cardiovascular disease, several lines of evidence suggest that it may play a role in atherothrombotic disease. Homocysteine appears to alter the anticoagulant properties of endothelial cells to a procoagulant phenotype. Mildly increased homocysteine causes dysfunction of the vascular endothelium. Folic acid effectively lowers homocysteine concentration in the plasma. Intervention studies are urgently needed to determine if lowering homocysteine is effective in decreasing the morbidity and mortality of cardiovascular disease.




The following articles in journals at HighWire Press have cited this article:


Home page
 Am J Crit CareHome page
E. K. Song, Y.-J. Son, and T. A. Lennie
Trait Anger, Hostility, Serum Homocysteine, and Recurrent Cardiac Events After Percutaneous Coronary Interventions
Am. J. Crit. Care., November 1, 2009; 18(6): 554 - 561.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. Gupta, J. Kuhnisch, A. Mustafa, S. Lhotak, A. Schlachterman, M. J. Slifker, A. Klein-Szanto, K. A. High, R. C. Austin, and W. D. Kruger
Mouse models of cystathionine {beta}-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia
FASEB J, March 1, 2009; 23(3): 883 - 893.
[Abstract] [Full Text] [PDF]

Home page
 EuropaceHome page
D. R. Van Wagoner
Is homocysteine a mediator of atrial dysfunction or just another marker of endothelial dysfunction?
Europace, August 1, 2008; 10(8): 899 - 900.
[Full Text] [PDF]

Home page
 ANGIOLOGYHome page
M. B.S. Kazemi, K. Eshraghian, G. R. Omrani, K. B. Lankarani, and E. Hosseini
Homocysteine Level and Coronary Artery Disease
Angiology, January 1, 2006; 57(1): 9 - 14.
[Abstract] [PDF]

Home page
 Hum ReprodHome page
E. B. Kilicdag, T. Bagis, E. Tarim, E. Aslan, S. Erkanli, E. Simsek, B. Haydardedeoglu, and E. Kuscu
Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial
Hum. Reprod., June 1, 2005; 20(6): 1521 - 1528.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
E. Bramanti, C. Vecoli, D. Neglia, M. P. Pellegrini, G. Raspi, and R. Barsacchi
Speciation and Quantification of Thiols by Reversed-Phase Chromatography Coupled with On-Line Chemical Vapor Generation and Atomic Fluorescence Spectrometric Detection: Method Validation and Preliminary Application for Glutathione Measurements in Human Whole Blood
Clin. Chem., June 1, 2005; 51(6): 1007 - 1013.
[Abstract] [Full Text] [PDF]

Home page
 ANGIOLOGYHome page
F. A. Pac, E. Ozerol, I. H. Ozerol, I. Temel, E. Ege, S. Yologlu, N. Sezgin, K. Sahin, M. Emmiler, M. Pac, et al.
Homocysteine, Lipid Profile, Nitric Oxide, Vitamin B12, and Folate Values in Patients with Premature Coronary Artery Disease and Their Children
Angiology, May 1, 2005; 56(3): 253 - 257.
[Abstract] [PDF]

Home page
 Vasc MedHome page
C. Chrysohoou, D. B Panagiotakos, C. Pitsavos, A. Zeimbekis, A. Zampelas, L. Papademetriou, C. Masoura, and C. Stefanadis
The associations between smoking, physical activity, dietary habits and plasma homocysteine levels in cardiovascular disease-free people: the 'ATTICA' study
Vascular Medicine, May 1, 2004; 9(2): 117 - 123.
[Abstract] [PDF]

Home page
 Clin. Chem.Home page
H. J. Huijgen, F. P.W. Tegelaers, C. H.H. Schoenmakers, C. J. Pronk-Admiraal, and S. Ekema
Multicenter Analytical Evaluation of an Enzymatic Method for the Measurement of Plasma Homocysteine and Comparison with HPLC and Immunochemistry
Clin. Chem., May 1, 2004; 50(5): 937 - 940.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
T. Arndt, B. Guessregen, A. Hohl, and B. Heicke
Total Plasma Homocysteine Measured by Liquid Chromatography-Tandem Mass Spectrometry with Use of 96-Well Plates
Clin. Chem., April 1, 2004; 50(4): 755 - 757.
[Full Text] [PDF]

Home page
 J Clin PharmacolHome page
R. Rodrigo, W. Passalacqua, J. Araya, M. Orellana, and G. Rivera
Homocysteine and Essential Hypertension
J. Clin. Pharmacol., December 1, 2003; 43(12): 1299 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
Y. Aso, K.-i. Okumura, K. Takebayashi, S. Wakabayashi, and T. Inukai
Relationships of Plasma Interleukin-18 Concentrations to Hyperhomocysteinemia and Carotid Intimal-Media Wall Thickness in Patients With Type 2 Diabetes
Diabetes Care, September 1, 2003; 26(9): 2622 - 2627.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Orio Jr., S. Palomba, S. Di Biase, A. Colao, L. Tauchmanova, S. Savastano, D. Labella, T. Russo, F. Zullo, and G. Lombardi
Homocysteine Levels and C677T Polymorphism of Methylenetetrahydrofolate Reductase in Women with Polycystic Ovary Syndrome
J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 673 - 679.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
Y.-F. Chen, P.-L. Li, and A.-P. Zou
Effect of Hyperhomocysteinemia on Plasma or Tissue Adenosine Levels and Renal Function
Circulation, September 3, 2002; 106(10): 1275 - 1281.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Li, F.-X. Yi, E. Rute, D. X. Zhang, G. R. Slocum, and A.-P. Zou
Effects of homocysteine on intracellular nitric oxide and superoxide levels in the renal arterial endothelium
Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H1237 - H1243.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
C. H. Hill, R. Mecham, and B. Starcher
Fibrillin-2 Defects Impair Elastic Fiber Assembly in a Homocysteinemic Chick Model
J. Nutr., August 1, 2002; 132(8): 2143 - 2150.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
R. RAGONE
Homocystine solubility and vascular disease
FASEB J, March 1, 2002; 16(3): 401 - 404.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. E Roeters van Lennep, H.T. Westerveld, D.W. Erkelens, and E. E van der Wall
Risk factors for coronary heart disease: implications of gender
Cardiovasc Res, February 15, 2002; 53(3): 538 - 549.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Sengupta, C. Wehbe, A. K. Majors, M. E. Ketterer, P. M. DiBello, and D. W. Jacobsen
Relative Roles of Albumin and Ceruloplasmin in the Formation of Homocystine, Homocysteine-Cysteine-mixed Disulfide, and Cystine in Circulation
J. Biol. Chem., December 7, 2001; 276(50): 46896 - 46904.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
D. M Kerins, M. J Koury, A. Capdevila, S. Rana, and C. Wagner
Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine
Am. J. Clinical Nutrition, December 1, 2001; 74(6): 723 - 729.
[Abstract] [Full Text]

Home page
 Clin. Chem.Home page
N. Matsuyama, M. Yamaguchi, M. Toyosato, M. Takayama, and K. Mizuno
New Enzymatic Colorimetric Assay for Total Homocysteine
Clin. Chem., December 1, 2001; 47(12): 2155 - 2156.
[Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
K. G Rowley, Q. Su, M. Cincotta, M. Skinner, K. Skinner, B. Pindan, G. A White, and K. O'Dea
Improvements in circulating cholesterol, antioxidants, and homocysteine after dietary intervention in an Australian Aboriginal community
Am. J. Clinical Nutrition, October 1, 2001; 74(4): 442 - 448.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. H. Williams, J. A. Maggiore, R. D. Reynolds, and C. M. Helgason
Novel Approach for the Determination of the Redox Status of Homocysteine and Other Aminothiols in Plasma from Healthy Subjects and Patients with Ischemic Stroke
Clin. Chem., June 1, 2001; 47(6): 1031 - 1039.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
W. Herrmann, H. Schorr, K. Purschwitz, F. Rassoul, and V. Richter
Total Homocysteine, Vitamin B12, and Total Antioxidant Status in Vegetarians
Clin. Chem., June 1, 2001; 47(6): 1094 - 1101.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
J. Crott and M. Fenech
Preliminary study of the genotoxic potential of homocysteine in human lymphocytes in vitro
Mutagenesis, May 1, 2001; 16(3): 213 - 217.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
J.-C. Minet, E. Bisse, C.-P. Aebischer, A. Beil, H. Wieland, and J. Lutschg
Assessment of vitamin B-12, folate, and vitamin B-6 status and relation to sulfur amino acid metabolism in neonates
Am. J. Clinical Nutrition, September 1, 2000; 72(3): 751 - 757.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H. Jakubowski, L. Zhang, A. Bardeguez, and A. Aviv
Homocysteine Thiolactone and Protein Homocysteinylation in Human Endothelial Cells : Implications for Atherosclerosis
Circ. Res., July 7, 2000; 87(1): 45 - 51.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. H. Mudd, J. D. Finkelstein, H. Refsum, P. M. Ueland, M. R. Malinow, S. R. Lentz, D. W. Jacobsen, L. Brattstrom, B. Wilcken, D. E. L. Wilcken, et al.
Homocysteine and Its Disulfide Derivatives : A Suggested Consensus Terminology
Arterioscler Thromb Vasc Biol, July 1, 2000; 20(7): 1704 - 1706.
[Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
D. G Weir and A. M Molloy
Microvascular disease and dementia in the elderly: are they related to hyperhomocysteinemia?
Am. J. Clinical Nutrition, April 1, 2000; 71(4): 859 - 860.
[Full Text] [PDF]

Home page
 J. Nutr.Home page
H. Jakubowski
Homocysteine Thiolactone: Metabolic Origin and Protein Homocysteinylation in Humans
J. Nutr., February 1, 2000; 130(2): 377 - 377.
[Abstract] [Full Text]

Home page
 FASEB J.Home page
H. JAKUBOWSKI
Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels
FASEB J, December 1, 1999; 13(15): 2277 - 2283.
[Abstract] [Full Text]

Home page
 Clin. Chem.Home page
J.-F. Salazar, B. Herbeth, G. Siest, and P. Leroy
Stability of Blood Homocysteine and Other Thiols: EDTA or Acidic Citrate?
Clin. Chem., November 1, 1999; 45(11): 2016 - 2019.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Cuer, S. Barrot, F. Jaureguy, D. Manene, G. Durand, and G. Le Moel
The Plasma Homocysteine/Creatinine Ratio Can Be Used to Study the Implication of (C677T) MTHFR Genetic Variants in Homocysteine Homeostasis
Clin. Chem., August 1, 1999; 45(8): 1312 - 1312.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. C. Martin, I. Tsakas-Ampatzis, W. A. Bartlett, and A. F. Jones
Measurement of Plasma Total Homocysteine by HPLC with Coulometric Detection
Clin. Chem., January 1, 1999; 45(1): 150 - 152.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Association for Clinical Chemistry.