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Portable Blood Gas and Electrolyte Analyzer Evaluated in a Multiinstitutional Study

¹ Department of Clinical Chemistry, University Hospital Rotterdam, 3000 CA Rotterdam, The Netherlands.

² Department of Pulmonology and Critical Care Medicine, Stanford University Medical Center, Stanford, CA 94305.

³ Institute Gustave-Roussy, Department of Clinical Chemistry, Villejuif F-94805, France.

⁴ Medizinische Hochschule Hannover, Institut für Klinische Chemie I, D-30623 Hannover, Germany.

⁵ Department of Clinical Chemistry and Hematology, Hospital Lievensberg, NL 4624 VT Bergen op Zoom, The Netherlands.
^a Address correspondence to this author at: Department of Clinical Chemistry, University Hospital Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. Fax 31 10 436 7894; e-mail lindemans{at}ckcl.azr.nl.

A recently introduced blood gas/electrolyte analyzer (SenDx 100^®, renamed ABL70) intended for point-of-care, near-patient, or stat laboratory use was evaluated simultaneously in four different institutions and compared with three different laboratory bench analyzers with respect to imprecision, inaccuracy (assessed by tonometry), and patient-sample analyses. The analyzer is equipped with a sensor cassette and a reagent cartridge for 50, 100, or 200 analyses and 100 or more traditional quality-control measurements. One analysis requires 170 µL of whole blood and takes <90 s. Statistically, the instrument performed somewhat better (lower CVs) for PO₂ and potassium and somewhat worse for pH, PCO₂, and ionized calcium than the respective comparison analyzers. However, the overall performance (in terms of CV and accuracy) was satisfactory in terms of clinical (e.g., CLIA '88) goals in all institutions. The mean difference and the CV of that difference in some 400 patient-sample comparisons were as follows: 0.010 (± 0.002%) for pH, -0.65 mmHg (± 4%) for PCO₂, -0.49 mmHg (± 6%) for Po₂, 0.44 mmol/L (± 1.2%) for sodium, -0.013 mmol/L (± 2.9%) for potassium, -0.016 mmol/L (± 2.6%) for ionized calcium, and -0.016 L/L (± 7.1%) for the hematocrit. Its acceptable analytical performance and ease of operation make the SenDx 100 suitable for the analysis of blood gases and electrolytes.

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