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Clinical Chemistry 45: 7-17, 1999;
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(Clinical Chemistry. 1999;45:7-17.)
© 1999 American Association for Clinical Chemistry, Inc.

Review

New Insights into the Role of Nuclear Factor-{kappa}B, a Ubiquitous Transcription Factor in the Initiation of Diseases

Fei Chen1,2,a, Vince Castranova1, Xianglin Shi1 and Laurence M. Demers2

1 Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505.

2 Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033.
a Author for correspondence. Fax (304) 285-5938; e-mail lfd3{at}cdc.gov.

Nuclear factor-{kappa}B (NF-{kappa}B) is a ubiquitous transcription factor that governs the expression of genes encoding cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NF-{kappa}B is activated by several agents, including cytokines, oxidant free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-{kappa}B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-{kappa}B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. Therefore, development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases.




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