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Clinical Chemistry 45: 1842-1849, 1999;
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(Clinical Chemistry. 1999;45:1842-1849.)
© 1999 American Association for Clinical Chemistry, Inc.

Articles

Serum Sialic Acid in a Random Sample of the General Population

Maritta Pönniö1,2, Hannu Alho3, Seppo T. Nikkari4, Ulf Olsson5, Ulf Rydberg2 and Pekka Sillanaukee1,2,4,a

1 Pharmacia & Upjohn Diagnostics AB, Alcohol Related Diseases, SE-112 87 Uppsala, Sweden.

2 Karolinska Institute, Department of Neuroscience, Medical School, 10401 Stockholm, Sweden.

3 National Public Health Institute, Alcohol Research Center, P. O. Box 719, FIN-00101 Helsinki, Finland and Research Unit of Alcohol Diseases, University of Helsinki, 00100 Helsinki, Finland.

4 University of Tampere Medical School and Tampere University Hospital, Department of Clinical Chemistry, 33101 Tampere, Finland.

5 Swedish University of Agricultural Sciences, Department of Statistics, Data Processing and Extension Education, P. O. Box 7013, S-750 07 Uppsala, Sweden.
a Address correspondence to this author at: Oy Finnish Immunotechnology, Ltd., Lenkkeilijänkatu 8, FIN-33520 Tampere, Finland. Fax 358 3 3138 7050; e-mail pekka.sillanaukee{at}fitltd.net

Background: The serum sialic acid (SA) concentration has been reported to be a potentially useful but nonspecific disease marker. We wanted to study which factors influence SA concentration in a well-characterized healthy population.

Methods: SA was determined in 97 women and 96 men with a colorimetric Warren method.

Results: The mean ± SD concentrations of SA were 634 ± 109 (95% confidence interval, 612–656) and 630 ± 106 (95% confidence interval, 608–651) mg/L for women and men, respectively. The serum SA showed a significant positive association with body mass index and with systolic and diastolic blood pressure among both women and men. SA also correlated significantly with the use of contraceptive pills and age among women and with smoking among men.

Conclusions: Our study suggests that SA does not increase with age in men but appears to increase with female menopause. The strong positive association with blood pressure may explain why SA predicts cardiovascular mortality.




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B. M.R. Appenzeller and R. Wennig
Altered Distribution of Transferrin Isoforms According to Serum Storage Conditions
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