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Articles |
1
Otsuka America Pharmaceutical, Inc., 2440 Research Blvd., Rockville, MD 20850.
2
Pacific Biometrics, Inc. Seattle, WA 98119.
3
Clinical Research Institute of Montreal, Montreal,
Quebec, Canada H2W 1R7.
4
University of Utah, Salt Lake City, UT 84108.
5
Cardiovascular Research Institute, University of
California, San Francisco, CA 94143.
6
All results are presented in SI units. To convert from SI units to "mg/dL", multiply the values by the following conversion factors: 38.61 for cholesterol, 88.50 for triglyceride, and 0.436 for the cholesterol (VLDL-C or RLP-C)-to-total triglyceride ratio. The upper limits of the reference intervals for the ratios of VLDL-C and RLP-C to total triglyceride are 0.69 and 0.23, respectively, for the SI values (or 0.30 and 0.10, respectively, for mg/dL).
a Author for correspondence. Fax 301-721-7213; e-mail TAOW{at}MOCR.OAPI.com
Background: Familial type III hyperlipoproteinemia (HLP) is characterized by the presence of ß-migrating VLDL (ß-VLDL) and increased risk of cardiovascular disease. Assessment of plasma ß-VLDL is achieved by measuring the ratio of VLDL-cholesterol (VLDL-C) to total plasma triglycerides (TGs) or by detecting ß-VLDL in total VLDL. The objective of this study was to compare the clinical utility of the ratio of remnant-like particle-cholesterol (RLP-C) to total TGs with that of the current methods for diagnosing type III HLP.
Methods: Detection of ß-VLDL by electrophoresis of VLDL was
used to define type III HLP. Twenty-eight patients with type III HLP
and 43 subjects lacking ß-VLDL were investigated. Fasting TG
concentrations were >2.26 mmol/L in all subjects. Subjects were
separated into three groups: group 1, serum total cholesterol 
5.18
mmol/L (n = 11); group 2, total cholesterol >5.18 mmol/L and TGs
between 2.26 and 9.04 mmol/L (n = 51); and group 3, TGs >9.04
mmol/L (n = 9).
Results: In group 2, a RLP-C-to-total TG molar ratio 
0.23
(0.10 when using mg/dL) and a VLDL-C-to-total TG molar ratio 0.69
(0.30 when using mg/dL) correctly classified 94% and 90% of the
subjects, respectively. The utility of the RLP-C-to-total TG ratio in
diagnosing type III HLP decreased in patients in the other two groups.
Conclusion: When used in an appropriate target population, the RLP-C-to-total TG ratio is a convenient and effective alternative to ultracentrifugal and electrophoretic methods for diagnosing type III HLP.
The following articles in journals at HighWire Press have cited this article:
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C. Marcoux, P. N. Hopkins, T. Wang, E. T. Leary, K. Nakajima, J. Davignon, and J. S. Cohn Remnant-like particle cholesterol and triglyceride levels of hypertriglyceridemic patients in the fed and fasted state J. Lipid Res., September 1, 2000; 41(9): 1428 - 1436. [Abstract] [Full Text]
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S. Hirany, D. O'Byrne, S. Devaraj, and I. Jialal Remnant-like Particle-Cholesterol Concentrations in Patients with Type 2 Diabetes Mellitus and End-Stage Renal Disease Clin. Chem., May 1, 2000; 46(5): 667 - 672. [Abstract] [Full Text] [PDF]
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