Clinical Chemistry Siemens Point of Care - Urinalysis
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 45: 1998-2004, 1999;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (35)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murr, C.
Right arrow Articles by Fuchs, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murr, C.
Right arrow Articles by Fuchs, D.
Related Collections
Right arrow General Clinical Chemistry
Right arrow Evidence Based Laboratory Medicine and Test Utilization
(Clinical Chemistry. 1999;45:1998-2004.)
© 1999 American Association for Clinical Chemistry, Inc.

Articles

Neopterin Is an Independent Prognostic Variable in Females with Breast Cancer

Christian Murr1, Anton Bergant2, Martin Widschwendter2, Kurt Heim2, Hans Schröcksnadel2 and Dietmar Fuchs1,a

1 Institute for Medical Chemistry and Biochemistry, and
2 Department for Gynecology and Obstetrics, University of Innsbruck, Fritz Pregl Strasse 3, A-6020 Innsbruck, Austria.
a Author for correspondence. Fax 43-512-507-2865; e-mail Dietmar.Fuchs{at}uibk.ac.at

Background: Neopterin, produced by human monocytes/macrophages upon stimulation by interferon-{gamma}, is a sensitive marker for monitoring Th1-cell immune response in humans. In malignant diseases, the frequency of increases in neopterin in the serum and urine of patients depends on tumor stage and type.

Methods: In a retrospective study comprising 129 females with breast cancer, urinary neopterin/creatinine ratios were measured at the time of diagnosis. Tumor characteristics were determined concomitantly.

Results: Urinary neopterin was increased in 18% of the patients. It did not correlate with tumor size or lymph node status, but it was influenced by the presence of distant metastases (P <0.05) and by tumor differentiation (P = 0.01). When product-limit estimates were calculated after follow-up for up to 13 years (median follow-up, 56 months), the presence of distant metastases (P <0.001), neopterin (P <0.001), tumor size (P = 0.001), and lymph node status (P <0.01) were significant predictors of survival. By multivariate analysis, a combination of the variables presence of distant metastases (P <0.001), neopterin (P <0.01), and lymph node status (P <0.05) was found to jointly predict survival. In lymph node-negative patients without distant metastases, the relative risk of death associated with increased neopterin concentrations was 2.5 compared with patients with neopterin concentrations within the reference interval.

Conclusion: Urinary neopterin provides additional prognostic information in patients with breast cancer.




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Cancer Res.Home page
M. Widschwendter and U. Menon
Circulating Methylated DNA: A New Generation of Tumor Markers
Clin. Cancer Res., December 15, 2006; 12(24): 7205 - 7208.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
K. Schroecksnadel, B. Frick, and D. Fuchs
Re: Plasma Folate, Vitamin B6, Vitamin B12, Homocysteine, and Risk of Breast Cancer
J Natl Cancer Inst, July 16, 2003; 95(14): 1091 - 1091.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
H. Schennach, C. Murr, C. Larcher, W. Streif, E. Pastner, D. Zaknun, D. Schonitzer, and D. Fuchs
Neopterin Concentrations in Cord Blood: A Single-Cohort Study of Paired Samples from 541 Pregnant Women and Their Newborns
Clin. Chem., November 1, 2002; 48(11): 2059 - 2061.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
H. Schennach, C. Murr, E. Gachter, P. Mayersbach, D. Schonitzer, and D. Fuchs
Factors Influencing Serum Neopterin Concentrations in a Population of Blood Donors
Clin. Chem., April 1, 2002; 48(4): 643 - 645.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the American Association for Clinical Chemistry.