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Articles |
1
Department of Laboratory Medicine, Children’s Hospital and Department of Pathology, Harvard Medical School, Boston, MA 02115.
2
Laboratory for Clinical Biochemistry Research,
University of Vermont, Burlington, VT 05446.
3
Divisions of Preventive Medicine and Cardiovascular
Disease and Department of Medicine, Brigham and Women’s Hospital,
Harvard Medical School, Boston, MA 02115.
a Address correspondence to this author at: Children’s Hospital, Department of Laboratory Medicine, 300 Longwood Ave., Boston, MA 02115. Fax 617-355-6081; e-mail rifai{at}a1.tch.harvard.edu
Background: Prospective studies have shown that C-reactive protein (CRP) can be used to predict risk of future cardiovascular events. High-sensitivity methods for CRP (hs-CRP) measurement are needed for this purpose.
Methods: We compared the clinical efficacy of an automated and commercially available latex-enhanced assay (Latex) for hs-CRP (Dade Behring) to a validated in-house ELISA, previously shown to predict future peripheral arterial disease (PAD) in asymptomatic populations. Using a prospective, nested, case-control design, we measured baseline hs-CRP concentrations in 144 apparently healthy men who subsequently developed symptomatic PAD and 144 age- and smoking habit-matched controls who remained free of vascular disease over the follow-up period of 60 months.
Results: The two hs-CRP assays correlated highly (r = 0.95; P <0.001), and all but two participants were classified into concordant quartiles or varied by only one quartile. The median hs-CRP of the case group was significantly higher than that of controls when measured by either the ELISA (1.34 vs 0.99 mg/L; P = 0.034) or the Latex method (1.80 vs 1.20 mg/L; P = 0.042). Furthermore, for both ELISA and the Latex method, the calculated relative risks of developing PAD increased significantly with each increasing quartile of hs-CRP. The calculated interquartile increase in relative risk of PAD was 31% (95% confidence interval, 5.2–62.2%; P = 0.01) for ELISA and 34% (95% confidence interval, 8.2–66.1%; P = 0.007) for the Latex method.
Conclusions: Our findings indicate that the Latex method is equally as efficacious as the validated ELISA in classifying patients into cutoff points established by prospective studies for risk stratification for coronary and cerebrovascular disease.
The following articles in journals at HighWire Press have cited this article:
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 F. Anan, T. Masaki, Y. Umeno, T. Iwao, H. Yonemochi, N. Eshima, T. Saikawa, and H. Yoshimatsu Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetic patients Eur. J. Endocrinol., September 1, 2007; 157(3): 311 - 317. [Abstract] [Full Text] [PDF]
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 O Rogowski, I Shapira, A Shirom, S Melamed, S Toker, and S Berliner Heart rate and microinflammation in men: a relevant atherothrombotic link Heart, August 1, 2007; 93(8): 940 - 944. [Abstract] [Full Text] [PDF]
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 J. Dierkes, C. Weikert, K. Klipstein-Grobusch, S. Westphal, C. Luley, M. Mohlig, J. Spranger, and H. Boeing Plasma pyridoxal-5-phosphate and future risk of myocardial infarction in the European Prospective Investigation into Cancer and Nutrition Potsdam cohort Am. J. Clinical Nutrition, July 1, 2007; 86(1): 214 - 220. [Abstract] [Full Text] [PDF]
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 T. Liu, G. Li, L. Li, and P. Korantzopoulos Association Between C-Reactive Protein and Recurrence of Atrial Fibrillation After Successful Electrical Cardioversion: A Meta-Analysis J. Am. Coll. Cardiol., April 17, 2007; 49(15): 1642 - 1648. [Abstract] [Full Text] [PDF]
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A. Hozawa, D. R. Jacobs Jr., M. W. Steffes, M. D. Gross, L. M. Steffen, and D.-H. Lee Relationships of Circulating Carotenoid Concentrations with Several Markers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: The Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) Study Clin. Chem., March 1, 2007; 53(3): 447 - 455. [Abstract] [Full Text] [PDF]
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 C. Herder, M. Peltonen, W. Koenig, I. Kraft, S. Muller-Scholze, S. Martin, T. Lakka, P. Ilanne-Parikka, J. G. Eriksson, H. Hamalainen, et al. Systemic Immune Mediators and Lifestyle Changes in the Prevention of Type 2 Diabetes: Results From the Finnish Diabetes Prevention Study. Diabetes, August 1, 2006; 55(8): 2340 - 2346. [Abstract] [Full Text] [PDF]
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 M. Juonala, J. S.A. Viikari, T. Ronnemaa, L. Taittonen, J. Marniemi, and O. T. Raitakari Childhood C-Reactive Protein in Predicting CRP and Carotid Intima-Media Thickness in Adulthood: The Cardiovascular Risk in Young Finns Study Arterioscler Thromb Vasc Biol, August 1, 2006; 26(8): 1883 - 1888. [Abstract] [Full Text] [PDF]
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 M. Takemura, H. Matsumoto, A. Niimi, T. Ueda, H. Matsuoka, M. Yamaguchi, M. Jinnai, S. Muro, T. Hirai, Y. Ito, et al. High sensitivity C-reactive protein in asthma. Eur. Respir. J., May 1, 2006; 27(5): 908 - 912. [Abstract] [Full Text] [PDF]
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T. W. McDade, L. C. Hawkley, and J. T. Cacioppo Psychosocial and Behavioral Predictors of Inflammation in Middle-Aged and Older Adults: The Chicago Health, Aging, and Social Relations Study Psychosom Med, May 1, 2006; 68(3): 376 - 381. [Abstract] [Full Text] [PDF]
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 S. M. O'BRIEN, L. V. SCOTT, and T. G. DINAN Antidepressant therapy and C-reactive protein levels The British Journal of Psychiatry, May 1, 2006; 188(5): 449 - 452. [Abstract] [Full Text] [PDF]
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Y. Ma, J. A Griffith, L. Chasan-Taber, B. C Olendzki, E. Jackson, E. J Stanek III, W. Li, S. L Pagoto, A. R Hafner, and I. S Ockene Association between dietary fiber and serum C-reactive protein. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 760 - 766. [Abstract] [Full Text] [PDF]
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 P. C. Kao, S.-C. Shiesh, and T.-J. Wu Serum C-reactive protein as a marker for wellness assessment. Ann. Clin. Lab. Sci., March 1, 2006; 36(2): 163 - 169. [Abstract] [Full Text] [PDF]
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C. Herder, S. Muller-Scholze, P. Rating, W. Koenig, B. Thorand, B. Haastert, R. Holle, T. Illig, W. Rathmann, J. Seissler, et al. Systemic monocyte chemoattractant protein-1 concentrations are independent of type 2 diabetes or parameters of obesity: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4) Eur. J. Endocrinol., February 1, 2006; 154(2): 311 - 317. [Abstract] [Full Text] [PDF]
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 L. G. Best, Y. Zhang, E. T. Lee, J.-L. Yeh, L. Cowan, V. Palmieri, M. Roman, R. B. Devereux, R. R. Fabsitz, R. P. Tracy, et al. C-Reactive Protein as a Predictor of Cardiovascular Risk in a Population With a High Prevalence of Diabetes: The Strong Heart Study Circulation, August 30, 2005; 112(9): 1289 - 1295. [Abstract] [Full Text] [PDF]
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T. Inoue, T. Kato, T. Uchida, M. Sakuma, A. Nakajima, M. Shibazaki, Y. Imoto, M. Saito, S. Hashimoto, Y. Hikichi, et al. Local Release of C-Reactive Protein From Vulnerable Plaque or Coronary Arterial Wall Injured by Stenting J. Am. Coll. Cardiol., July 19, 2005; 46(2): 239 - 245. [Abstract] [Full Text] [PDF]
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M. Cushman, A. M. Arnold, B. M. Psaty, T. A. Manolio, L. H. Kuller, G. L. Burke, J. F. Polak, and R. P. Tracy C-Reactive Protein and the 10-Year Incidence of Coronary Heart Disease in Older Men and Women: The Cardiovascular Health Study Circulation, July 5, 2005; 112(1): 25 - 31. [Abstract] [Full Text] [PDF]
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P. M. Okin, M. J. Roman, L. G. Best, E. T. Lee, J. M. Galloway, B. V. Howard, and R. B. Devereux C-Reactive Protein and Electrocardiographic ST-Segment Depression Additively Predict Mortality: The Strong Heart Study J. Am. Coll. Cardiol., June 7, 2005; 45(11): 1787 - 1793. [Abstract] [Full Text] [PDF]
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 G. M. Hirschfield, J. R. Gallimore, M. C. Kahan, W. L. Hutchinson, C. A. Sabin, G. M. Benson, A. P. Dhillon, G. A. Tennent, and M. B. Pepys Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice PNAS, June 7, 2005; 102(23): 8309 - 8314. [Abstract] [Full Text] [PDF]
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A. W. Zieske, R. P. Tracy, C. A. McMahan, E. E. Herderick, S. Homma, G. T. Malcom, H. C. McGill Jr, J. P. Strong, and for the Pathobiological Determinants of Atheroscle Elevated Serum C-Reactive Protein Levels and Advanced Atherosclerosis in Youth Arterioscler Thromb Vasc Biol, June 1, 2005; 25(6): 1237 - 1243. [Abstract] [Full Text] [PDF]
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R. Rej Clinical Chemistry through Clinical Chemistry: A Journal Timeline Clin. Chem., December 1, 2004; 50(12): 2415 - 2458. [Abstract] [Full Text] [PDF]
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T. Illig, F. Bongardt, A. Schopfer, S. Muller-Scholze, W. Rathmann, W. Koenig, B. Thorand, C. Vollmert, R. Holle, H. Kolb, et al. Significant Association of the Interleukin-6 Gene Polymorphisms C-174G and A-598G with Type 2 Diabetes J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 5053 - 5058. [Abstract] [Full Text] [PDF]
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S. Melamed, A. Shirom, S. Toker, S. Berliner, and I. Shapira Association of Fear of Terror With Low-Grade Inflammation Among Apparently Healthy Employed Adults Psychosom Med, July 1, 2004; 66(4): 484 - 491. [Abstract] [Full Text] [PDF]
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Yasmin, C. M. McEniery, S. Wallace, I. S. Mackenzie, J. R. Cockcroft, and I. B. Wilkinson C-Reactive Protein Is Associated With Arterial Stiffness in Apparently Healthy Individuals Arterioscler Thromb Vasc Biol, May 1, 2004; 24(5): 969 - 974. [Abstract] [Full Text]
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R. V. Milani, C. J. Lavie, and M. R. Mehra Reduction in C-reactive protein through cardiac rehabilitation and exercise training J. Am. Coll. Cardiol., March 17, 2004; 43(6): 1056 - 1061. [Abstract] [Full Text] [PDF]
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T. W. McDade, J. Burhop, and J. Dohnal High-Sensitivity Enzyme Immunoassay for C-Reactive Protein in Dried Blood Spots Clin. Chem., March 1, 2004; 50(3): 652 - 654. [Full Text] [PDF]
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D Zeltser, O Rogowski, S Berliner, T Mardi, D Justo, J Serov, M Rozenblat, D Avitzour, and I Shapira Sex differences in the expression of haemorheological determinants in individuals with atherothrombotic risk factors and in apparently healthy people Heart, March 1, 2004; 90(3): 277 - 281. [Abstract] [Full Text] [PDF]
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 C. R. Narins, W. Zareba, A. J. Moss, V. J. Marder, P. M. Ridker, R. J. Krone, and E. Lichstein Relationship Between Intermittent Claudication, Inflammation, Thrombosis, and Recurrent Cardiac Events Among Survivors of Myocardial Infarction Arch Intern Med, February 23, 2004; 164(4): 440 - 446. [Abstract] [Full Text] [PDF]
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H. K. Meier-Ewert, P. M. Ridker, N. Rifai, M. M. Regan, N. J. Price, D. F. Dinges, and J. M. Mullington Effect of sleep loss on C-Reactive protein, an inflammatory marker of cardiovascular risk J. Am. Coll. Cardiol., February 18, 2004; 43(4): 678 - 683. [Abstract] [Full Text] [PDF]
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 T. P. Erlinger, E. A. Platz, N. Rifai, and K. J. Helzlsouer C-Reactive Protein and the Risk of Incident Colorectal Cancer JAMA, February 4, 2004; 291(5): 585 - 590. [Abstract] [Full Text] [PDF]
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B. J. Ansell, M. Navab, S. Hama, N. Kamranpour, G. Fonarow, G. Hough, S. Rahmani, R. Mottahedeh, R. Dave, S. T. Reddy, et al. Inflammatory/Antiinflammatory Properties of High-Density Lipoprotein Distinguish Patients From Control Subjects Better Than High-Density Lipoprotein Cholesterol Levels and Are Favorably Affected by Simvastatin Treatment Circulation, December 2, 2003; 108(22): 2751 - 2756. [Abstract] [Full Text] [PDF]
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T. Illig, F. Bongardt, A. Schopfer, R. Holle, S. Muller, W. Rathmann, W. Koenig, C. Meisinger, H.-E. Wichmann, and H. Kolb The Endotoxin Receptor TLR4 Polymorphism Is Not Associated With Diabetes or Components of the Metabolic Syndrome Diabetes, November 1, 2003; 52(11): 2861 - 2864. [Full Text] [PDF]
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 D. M Cummings, D. E King, and A. G Mainous III C-Reactive Protein, Antiinflammatory Drugs, and Quality of Life in Diabetes Ann. Pharmacother., November 1, 2003; 37(11): 1593 - 1597. [Abstract] [Full Text] [PDF]
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 S. Nakanishi, K. Yamane, N. Kamei, M. Okubo, and N. Kohno Elevated C-Reactive Protein Is a Risk Factor for the Development of Type 2 Diabetes in Japanese Americans Diabetes Care, October 1, 2003; 26(10): 2754 - 2757. [Abstract] [Full Text] [PDF]
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V. Palmieri, R. P. Tracy, M. J. Roman, J. E. Liu, L. G. Best, J. N. Bella, D. C. Robbins, B. V. Howard, and R. B. Devereux Relation of Left Ventricular Hypertrophy to Inflammation and Albuminuria in Adults With Type 2 Diabetes: The Strong Heart Study Diabetes Care, October 1, 2003; 26(10): 2764 - 2769. [Abstract] [Full Text] [PDF]
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N. Khuseyinova, A. Imhof, G. Trischler, D. Rothenbacher, W. L. Hutchinson, M. B. Pepys, and W. Koenig Determination of C-Reactive Protein: Comparison of Three High-Sensitivity Immunoassays Clin. Chem., October 1, 2003; 49(10): 1691 - 1695. [Full Text] [PDF]
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M. M. Engler, M. B. Engler, M. J. Malloy, E. Y. Chiu, M. C. Schloetter, S. M. Paul, M. Stuehlinger, K. Y. Lin, J. P. Cooke, J. D. Morrow, et al. Antioxidant Vitamins C and E Improve Endothelial Function in Children With Hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial Circulation, September 2, 2003; 108(9): 1059 - 1063. [Abstract] [Full Text] [PDF]
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R. Retnakaran, A. J. G. Hanley, N. Raif, P. W. Connelly, M. Sermer, and B. Zinman C-Reactive Protein and Gestational Diabetes: The Central Role of Maternal Obesity J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3507 - 3512. [Abstract] [Full Text] [PDF]
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M. H. Shishehbor, R. J. Aviles, M.-L. Brennan, X. Fu, M. Goormastic, G. L. Pearce, N. Gokce, J. F. Keaney Jr, M. S. Penn, D. L. Sprecher, et al. Association of Nitrotyrosine Levels With Cardiovascular Disease and Modulation by Statin Therapy JAMA, April 2, 2003; 289(13): 1675 - 1680. [Abstract] [Full Text] [PDF]
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M. M. Kimberly, H. W. Vesper, S. P. Caudill, G. R. Cooper, N. Rifai, F. Dati, and G. L. Myers Standardization of Immunoassays for Measurement of High-Sensitivity C-reactive Protein. Phase I: Evaluation of Secondary Reference Materials Clin. Chem., April 1, 2003; 49(4): 611 - 616. [Abstract] [Full Text] [PDF]
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N. Rifai and P. M. Ridker Population Distributions of C-reactive Protein in Apparently Healthy Men and Women in the United States: Implication for Clinical Interpretation Clin. Chem., April 1, 2003; 49(4): 666 - 669. [Full Text] [PDF]
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A. Imhof, M. Frohlich, H. Loewel, N. Helbecque, M. Woodward, P. Amouyel, G. D.O. Lowe, and W. Koenig Distributions of C-reactive Protein Measured by High-Sensitivity Assays in Apparently Healthy Men and Women from Different Populations in Europe Clin. Chem., April 1, 2003; 49(4): 669 - 672. [Full Text] [PDF]
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 Y. Y. Fadl, W. Zareba, A. J. Moss, V. J. Marder, C. S. Sparks, L. F. Miller Watelet, and E. R. Carroll History of Hypertension and Enhanced Thrombogenic Activity in Postinfarction Patients Hypertension, April 1, 2003; 41(4): 943 - 949. [Abstract] [Full Text] [PDF]
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G. J. Blake, J. D. Otvos, N. Rifai, and P. M Ridker Low-Density Lipoprotein Particle Concentration and Size as Determined by Nuclear Magnetic Resonance Spectroscopy as Predictors of Cardiovascular Disease in Women Circulation, October 8, 2002; 106(15): 1930 - 1937. [Abstract] [Full Text] [PDF]
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S. Verma, C.-H. Wang, S.-H. Li, A. S. Dumont, P. W.M. Fedak, M. V. Badiwala, B. Dhillon, R. D. Weisel, R.-K. Li, D. A.G. Mickle, et al. A Self-Fulfilling Prophecy: C-Reactive Protein Attenuates Nitric Oxide Production and Inhibits Angiogenesis Circulation, August 20, 2002; 106(8): 913 - 919. [Abstract] [Full Text] [PDF]
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R. Hayaishi-Okano, Y. Yamasaki, N. Katakami, K. Ohtoshi, S.-I. Gorogawa, A. Kuroda, M. Matsuhisa, K. Kosugi, N. Nishikawa, Y. Kajimoto, et al. Elevated C-Reactive Protein Associates With Early-Stage Carotid Atherosclerosis in Young Subjects With Type 1 Diabetes Diabetes Care, August 1, 2002; 25(8): 1432 - 1438. [Abstract] [Full Text] [PDF]
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M. Ishibashi, Y. Takemura, H. Ishida, K. Watanabe, and T. Kawai C-Reactive Protein Kinetics in Newborns: Application of a High-Sensitivity Analytic Method in Its Determination Clin. Chem., July 1, 2002; 48(7): 1103 - 1106. [Full Text] [PDF]
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C. M. Albert, J. Ma, N. Rifai, M. J. Stampfer, and P. M. Ridker Prospective Study of C-Reactive Protein, Homocysteine, and Plasma Lipid Levels as Predictors of Sudden Cardiac Death Circulation, June 4, 2002; 105(22): 2595 - 2599. [Abstract] [Full Text] [PDF]
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D. C. Chan, G. F. Watts, P. H. R. Barrett, L. J. Beilin, and T. A. Mori Effect of Atorvastatin and Fish Oil on Plasma High-Sensitivity C-Reactive Protein Concentrations in Individuals with Visceral Obesity Clin. Chem., June 1, 2002; 48(6): 877 - 883. [Abstract] [Full Text] [PDF]
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I. M. van der Meer, M. P.M. de Maat, M. L. Bots, M. M.B. Breteler, J. Meijer, A. J. Kiliaan, A. Hofman, and J. C.M. Witteman Inflammatory Mediators and Cell Adhesion Molecules as Indicators of Severity of Atherosclerosis: The Rotterdam Study Arterioscler Thromb Vasc Biol, May 1, 2002; 22(5): 838 - 842. [Abstract] [Full Text] [PDF]
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 N. Rifai, J. E. Buring, I-M. Lee, J. E. Manson, and P. M Ridker Is C-Reactive Protein Specific for Vascular Disease in Women? Ann Intern Med, April 2, 2002; 136(7): 529 - 533. [Abstract] [Full Text] [PDF]
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P. Libby, P. M. Ridker, and A. Maseri Inflammation and Atherosclerosis Circulation, March 5, 2002; 105(9): 1135 - 1143. [Abstract] [Full Text] [PDF]
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P. Tarkkinen, T. Palenius, and T. Lovgren Ultrarapid, Ultrasensitive One-Step Kinetic Immunoassay for C-Reactive Protein (CRP) in Whole Blood Samples: Measurement of the Entire CRP Concentration Range with a Single Sample Dilution Clin. Chem., February 1, 2002; 48(2): 269 - 277. [Abstract] [Full Text] [PDF]
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G. J. Blake, N. Dada, J. C. Fox, J. E. Manson, and P. M. Ridker A prospective evaluation of lipoprotein-associated phospholipase A2 levels and the risk of future cardiovascular events in women J. Am. Coll. Cardiol., November 1, 2001; 38(5): 1302 - 1306. [Abstract] [Full Text] [PDF]
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A. D. Pradhan, J. E. Manson, N. Rifai, J. E. Buring, and P. M. Ridker C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus JAMA, July 18, 2001; 286(3): 327 - 334. [Abstract] [Full Text] [PDF]
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P. M. Ridker, N. Rifai, M. Clearfield, J. R. Downs, S. E. Weis, J. S. Miles, A. M. Gotto Jr., and the Air Force/Texas Coronary Atherosclerosis Preve Measurement of C-Reactive Protein for the Targeting of Statin Therapy in the Primary Prevention of Acute Coronary Events N. Engl. J. Med., June 28, 2001; 344(26): 1959 - 1965. [Abstract] [Full Text] [PDF]
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P. M. Ridker, M. J. Stampfer, and N. Rifai Novel Risk Factors for Systemic Atherosclerosis: A Comparison of C-Reactive Protein, Fibrinogen, Homocysteine, Lipoprotein(a), and Standard Cholesterol Screening as Predictors of Peripheral Arterial Disease JAMA, May 16, 2001; 285(19): 2481 - 2485. [Abstract] [Full Text] [PDF]
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P. M. Ridker High-Sensitivity C-Reactive Protein : Potential Adjunct for Global Risk Assessment in the Primary Prevention of Cardiovascular Disease Circulation, April 3, 2001; 103(13): 1813 - 1818. [Abstract] [Full Text] [PDF]
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P. M. Ridker, N. Rifai, and S. P. Lowenthal Rapid Reduction in C-Reactive Protein With Cerivastatin Among 785 Patients With Primary Hypercholesterolemia Circulation, March 6, 2001; 103(9): 1191 - 1193. [Abstract] [Full Text] [PDF]
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N. Rifai and P. M. Ridker High-Sensitivity C-Reactive Protein: A Novel and Promising Marker of Coronary Heart Disease Clin. Chem., March 1, 2001; 47(3): 403 - 411. [Abstract] [Full Text] [PDF]
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W. L. Roberts, L. Moulton, T. C. Law, G. Farrow, M. Cooper-Anderson, J. Savory, and N. Rifai Evaluation of Nine Automated High-Sensitivity C-Reactive Protein Methods: Implications for Clinical and Epidemiological Applications. Part 2 Clin. Chem., March 1, 2001; 47(3): 418 - 425. [Abstract] [Full Text] [PDF]
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H. K. Meier-Ewert, P. M. Ridker, N. Rifai, N. Price, D. F. Dinges, and J. M. Mullington Absence of Diurnal Variation of C-Reactive Protein Concentrations in Healthy Human Subjects Clin. Chem., March 1, 2001; 47(3): 426 - 430. [Abstract] [Full Text] [PDF]
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I. S. Ockene, C. E. Matthews, N. Rifai, P. M. Ridker, G. Reed, and E. Stanek Variability and Classification Accuracy of Serial High-Sensitivity C-Reactive Protein Measurements in Healthy Adults Clin. Chem., March 1, 2001; 47(3): 444 - 450. [Abstract] [Full Text] [PDF]
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W. Koenig C-Reactive Protein and Cardiovascular Risk: Has the Time Come for Screening the General Population? Clin. Chem., January 1, 2001; 47(1): 9 - 10. [Full Text] [PDF]
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N. Rifai and P. M. Ridker Proposed Cardiovascular Risk Assessment Algorithm Using High-Sensitivity C-Reactive Protein and Lipid Screening Clin. Chem., January 1, 2001; 47(1): 28 - 30. [Full Text] [PDF]
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S. G. Priori, C. Napolitano, N. Tiso, M. Memmi, G. Vignati, R. Bloise, V. Sorrentino, and G. A. Danieli Mutations in the Cardiac Ryanodine Receptor Gene (hRyR2) Underlie Catecholaminergic Polymorphic Ventricular Tachycardia Circulation, December 6, 2000; (2000) 11. [Abstract] [Full Text]
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G. Sesmilo, B. M.K. Biller, J. Llevadot, D. Hayden, G. Hanson, N. Rifai, and A. Klibanski Effects of Growth Hormone Administration on Inflammatory and Other Cardiovascular Risk Markers in Men with Growth Hormone Deficiency: A Randomized, Controlled Clinical Trial Ann Intern Med, July 18, 2000; 133(2): 111 - 122. [Abstract] [Full Text] [PDF]
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R. F. Redberg, N. Rifai, L. Gee, and P. M. Ridker Lack of association of C-reactive protein and coronary calcium by electron beam computed tomography in postmenopausal women: implications for coronary artery disease screening J. Am. Coll. Cardiol., July 1, 2000; 36(1): 39 - 43. [Abstract] [Full Text] [PDF]
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W. L. Hutchinson, W. Koenig, M. Frohlich, M. Sund, G. D.O. Lowe, and M. B. Pepys Immunoradiometric Assay of Circulating C-Reactive Protein: Age-related Values in the Adult General Population Clin. Chem., July 1, 2000; 46(7): 934 - 938. [Abstract] [Full Text] [PDF]
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W. L. Roberts, R. Sedrick, L. Moulton, A. Spencer, and N. Rifai Evaluation of Four Automated High-Sensitivity C-Reactive Protein Methods: Implications for Clinical and Epidemiological Applications Clin. Chem., April 1, 2000; 46(4): 461 - 468. [Abstract] [Full Text] [PDF]
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P. M. Ridker, C. H. Hennekens, J. E. Buring, and N. Rifai C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women N. Engl. J. Med., March 23, 2000; 342(12): 836 - 843. [Abstract] [Full Text] [PDF]
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M. K. Chung, D. O. Martin, D. Sprecher, O. Wazni, A. Kanderian, C. A. Carnes, J. A. Bauer, P. J. Tchou, M. J. Niebauer, A. Natale, et al. C-Reactive Protein Elevation in Patients With Atrial Arrhythmias: Inflammatory Mechanisms and Persistence of Atrial Fibrillation Circulation, December 11, 2001; 104(24): 2886 - 2891. [Abstract] [Full Text] [PDF]
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S. Verma, S.-H. Li, M. V. Badiwala, R. D. Weisel, P. W.M. Fedak, R.-K. Li, B. Dhillon, and D. A.G. Mickle Endothelin Antagonism and Interleukin-6 Inhibition Attenuate the Proatherogenic Effects of C-Reactive Protein Circulation, April 23, 2002; 105(16): 1890 - 1896. [Abstract] [Full Text] [PDF]
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A. P. Burke, R. P. Tracy, F. Kolodgie, G. T. Malcom, A. Zieske, R. Kutys, J. Pestaner, J. Smialek, and R. Virmani Elevated C-Reactive Protein Values and Atherosclerosis in Sudden Coronary Death: Association With Different Pathologies Circulation, April 30, 2002; 105(17): 2019 - 2023. [Abstract] [Full Text] [PDF]
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