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Articles |
1
Hennepin County Medical Center, Minneapolis, MN 55415.
2
Rush Presbyterian St. Luke's Medical Center, Chicago,
IL 60612.
3
Emory University Hospital, Atlanta, GA 30322.
4
University of Tennessee Memorial Hospital, Knoxville, TN
37920.
5
Columbia Presbyterian Medical Center, New York, NY
10032.
6
University of Maryland School of Medicine, Baltimore, MD
21201.
a Address correspondence to this author at: Hennepin County Medical Center, Clinical Laboratories 812, 701 Park Ave., Minneapolis, MN 55415. Fax 612-904-4229; e-mail fred.apple{at}co.hennepin.mn.us.
We evaluated the AxSYM troponin I (cTnI) immunoassay for assisting in
the detection of acute myocardial infarction (AMI). At four sites, the
total imprecision (CV) over 20 days was 6.3–10.2%. The minimum
detectable concentration was 0.14 ± 0.05 µg/L. Comparison of
cTnI measurements between the AxSYM and Stratus (n = 406) over the
dynamic range of the AxSYM assay demonstrated good correlation,
r = 0.881, with a proportional bias: AxSYM
cTnI = 3.50(Stratus cTnI) - 1.10. The confidence intervals (95%)
for the slope and intercept were 3.39–3.64 and -1.32 to -0.95,
respectively. The expected cTnI concentration in healthy individuals
was 
0.5 µg/L, whereas the ROC curve-determined cutoff for AMI was
2.0 µg/L. This gave a diagnostic sensitivity of 91.8% and
specificity of 92.4% when tested in serial samples collected within
24 h of admission in 633 patients presenting with chest pain, of
which 122 had an AMI. The concordances of the AxSYM cTnI with the
Stratus cTnI, OPUS cTnI, and Access cTnI were 95.3%, 95.1%, and
94.3%, respectively, from patients with suspected AMI. The AxSYM cTnI
demonstrated excellent clinical specificity, 
96%, in skeletal muscle
injury, chronic renal disease, and same-day noncardiac surgery
patients.
The following articles in journals at HighWire Press have cited this article:
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  U. K. Chowdhury, V. Malik, R. Yadav, S. Seth, L. Ramakrishnan, M. Kalaivani, S. M. Reddy, G. K. Subramaniam, R. Govindappa, and M. Kakani Myocardial injury in coronary artery bypass grafting: On-pump versus off-pump comparison by measuring high-sensitivity C-reactive protein, cardiac troponin I, heart-type fatty acid-binding protein, creatine kinase-MB, and myoglobin release. J. Thorac. Cardiovasc. Surg., May 1, 2008; 135(5): 1110 - 1119.e10. [Abstract] [Full Text] [PDF]
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 D. A. Waxman, S. Hecht, J. Schappert, and G. Husk A Model for Troponin I as a Quantitative Predictor of In-Hospital Mortality J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1755 - 1762. [Abstract] [Full Text] [PDF]
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 Q. Lam, M. Black, O. Youdell, H. Spilsbury, and H.-G. Schneider Performance Evaluation and Subsequent Clinical Experience with the Abbott Automated Architect STAT Troponin-I Assay Clin. Chem., February 1, 2006; 52(2): 298 - 300. [Abstract] [Full Text] [PDF]
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D. M. Bunk and M. J. Welch Characterization of a New Certified Reference Material for Human Cardiac Troponin I Clin. Chem., February 1, 2006; 52(2): 212 - 219. [Abstract] [Full Text] [PDF]
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D. Ritter, P. A. Lee, J. F. Taylor, L. Hsu, J. D. Cohen, H. D. Chung, and K. S. Virgo Troponin I in Patients without Chest Pain Clin. Chem., January 1, 2004; 50(1): 112 - 119. [Abstract] [Full Text] [PDF]
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 J. B. Ryan, M. Hicks, J. R. Cropper, S. R. Garlick, S. H. Kesteven, M. K. Wilson, M. P. Feneley, and P. S. Macdonald The initial rate of troponin I release post-reperfusion reflects the effectiveness of myocardial protection during cardiac allograft preservation Eur. J. Cardiothorac. Surg., June 1, 2003; 23(6): 898 - 906. [Abstract] [Full Text] [PDF]
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R. Labugger, J. A. Simpson, M. Quick, H. A. Brown, C. E. Collier, I. Neverova, and J. E. Van Eyk Strategy for Analysis of Cardiac Troponins in Biological Samples with a Combination of Affinity Chromatography and Mass Spectrometry Clin. Chem., June 1, 2003; 49(6): 873 - 879. [Abstract] [Full Text] [PDF]
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 E. J. Fransen, J. H. C. Diris, J. G. Maessen, W. Th. Hermens, and M. P. van Dieijen-Visser Evaluation of "New" Cardiac Markers for Ruling Out Myocardial Infarction After Coronary Artery Bypass Grafting Chest, October 1, 2002; 122(4): 1316 - 1321. [Abstract] [Full Text] [PDF]
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M. Panteghini Acute Coronary Syndrome: Biochemical Strategies in the Troponin Era Chest, October 1, 2002; 122(4): 1428 - 1435. [Abstract] [Full Text] [PDF]
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D. Peetz, G. Hafner, and K. J. Lackner Analytical Characteristics of the AxSYM Cardiac Troponin I and Creatine Kinase MB Assays Clin. Chem., July 1, 2002; 48(7): 1110 - 1111. [Full Text] [PDF]
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D. Uettwiller-Geiger, A. H.B. Wu, F. S. Apple, A. W. Jevans, P. Venge, M. D. Olson, C. Darte, D. L. Woodrum, S. Roberts, and S. Chan Multicenter Evaluation of an Automated Assay for Troponin I Clin. Chem., June 1, 2002; 48(6): 869 - 876. [Abstract] [Full Text] [PDF]
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P. Venge, B. Lindahl, and L. Wallentin New Generation Cardiac Troponin I Assay for the Access Immunoassay System Clin. Chem., May 1, 2001; 47(5): 959 - 961. [Full Text] [PDF]
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R. H. Christenson, S. H. Duh, F. S. Apple, G. S. Bodor, D. M. Bunk, J. Dalluge, M. Panteghini, J. D. Potter, M. J. Welch, A. H.B. Wu, et al. Standardization of Cardiac Troponin I Assays: Round Robin of Ten Candidate Reference Materials Clin. Chem., March 1, 2001; 47(3): 431 - 437. [Abstract] [Full Text] [PDF]
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R. H. Christenson, S. H. Duh, W. R. Sanhai, A. H.B. Wu, V. Holtman, P. Painter, E. Branham, F. S. Apple, M. Murakami, and D. L. Morris Characteristics of an Albumin Cobalt Binding Test for Assessment of Acute Coronary Syndrome Patients: A Multicenter Study Clin. Chem., March 1, 2001; 47(3): 464 - 470. [Abstract] [Full Text] [PDF]
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J. C.J.M. Swaanenburg, B. G. Loef, M. Volmer, P. W. Boonstra, J. G. Grandjean, M. A. Mariani, and A. H. Epema Creatine Kinase MB, Troponin I, and Troponin T Release Patterns after Coronary Artery Bypass Grafting with or without Cardiopulmonary Bypass and after Aortic and Mitral Valve Surgery Clin. Chem., March 1, 2001; 47(3): 584 - 587. [Full Text] [PDF]
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J.-P. Chapelle, M.-C. Aldenhoff, L. Pierard, and J. Gielen Comparison of Cardiac Troponin I Measurements on Whole Blood and Plasma on the Stratus CS Analyzer and Comparison with AxSYM Clin. Chem., November 1, 2000; 46(11): 1864 - 1866. [Full Text] [PDF]
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G. Boriani, M. Biffi, V. Cervi, G. Bronzetti, G. Magagnoli, R. Zannoli, and A. Branzi Evaluation of Myocardial Injury Following Repeated Internal Atrial Shocks by Monitoring Serum Cardiac Troponin I Levels Chest, August 1, 2000; 118(2): 342 - 347. [Abstract] [Full Text] [PDF]
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 C. W. Hamm and E. Braunwald A Classification of Unstable Angina Revisited Circulation, July 4, 2000; 102(1): 118 - 122. [Abstract] [Full Text] [PDF]
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S. Fredericks, P. O. Collinson, D. W. Holt, P. A. Isotalo, D. C. Greenway, and J. G. Donnelly Response to ""Increased Creatine Kinase MB and Cardiac Troponin T with Normal Cardiac Troponin I in Metastatic Alveolar Rhabdomyosarcoma"" • The authors of the Letter cited above reply: Clin. Chem., March 1, 2000; 46(3): 432 - 435. [Full Text] [PDF]
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S. L. Braun, A. Barankay, and D. Mazzitelli Plasma Troponin T and Troponin I after Minimally Invasive Coronary Bypass Surgery Clin. Chem., February 1, 2000; 46(2): 279 - 281. [Full Text] [PDF]
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D. H. Wilson, D. M. Laird, C. M. Forsythe, T. T. Biegalski, A. L. Keller, and R. J. Herrmann Antibody Selection for the Abbott AxSYM Troponin I Assay Clin. Chem., December 1, 1999; 45(12): 2293 - 2294. [Full Text] [PDF]
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C. Heeschen, B. U. Goldmann, L. Langenbrink, G. Matschuck, and C. W. Hamm Evaluation of a Rapid Whole Blood ELISA for Quantification of Troponin I in Patients with Acute Chest Pain Clin. Chem., October 1, 1999; 45(10): 1789 - 1796. [Abstract] [Full Text] [PDF]
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