HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit an electronic Letter to the Editor about this paper Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Vezzoli, G. Articles by Soldati, L. Search for Related Content PubMed PubMed Citation Articles by Vezzoli, G. Articles by Soldati, L. Related Collections Endocrinology and Metabolism

Study of Calcium Metabolism in Idiopathic Hypercalciuria by Strontium Oral Load Test

^a Address correspondence to this author at: Divisione Nefrologia, Dialisi e Ipertensione, Ospedale San Raffaele, Via Olgettina 60, 20132 Milano, Italy. Fax 2-26432384; e-mail vezzoli.giuseppe{at}hsr.it.

Calcium excretion and absorption were evaluated in hypercalciuric calcium stone formers by the study of Sr²⁺ excretion and absorption after an oral load. Ca²⁺ stone formers (n = 140) were studied, and the results were compared in the 83 of them who had idiopathic hypercalciuria and in the 57 who had Ca²⁺ excretion within reference values. Hypercalciuric patients showed increased renal Sr²⁺ clearance (CR_E; 5.26 ± 0.358 vs 3.29 ± 0.277 mL/min; P <0.001), whereas Sr²⁺ absorption [assessed as the area under the serum concentration–time curve (AUC)] was increased at 30 and 60 min (1.53 ± 0.087 vs 1.21 ± 0.071 mmol · L^-1 · min; P <0.05), but not at 240 min after the load. In hypercalciuric patients, the AUCs were positively correlated with urinary Sr²⁺ fractional excretion (P <0.001). Conversely, in normocalciuric patients plasma parathyroid hormone (PTH) was negatively correlated with the AUCs (P <0.01) and CR_E (P <0.05), whereas 1,25-dihydroxyvitamin D plasma concentrations normalized to PTH were positively correlated with the AUCs (P <0.05). The results of Sr²⁺ load tests suggest that in the hypercalciuric population, Ca²⁺ absorption is altered predominantly in the duodenum and that the normal regulation exerted by calciotropic hormones on tubular and enteral Ca²⁺ handling is lost.

The following articles in journals at HighWire Press have cited this article:

				L. Soldati, D. Adamo, C. Bianchin, T. Arcidiacono, A. Terranegra, M. L. Bianchi, S. Mora, D. Cusi, and G. Vezzoli Vitamin D Receptor mRNA Measured in Leukocytes with the TaqMan Fluorogenic Detection System: Effect of Calcitriol Administration Clin. Chem., August 1, 2004; 50(8): 1315 - 1321. [Abstract] [Full Text] [PDF]

				G. Vezzoli, A. Tanini, L. Ferrucci, L. Soldati, C. Bianchin, F. Franceschelli, C. Malentacchi, B. Porfirio, D. Adamo, A. Terranegra, et al. Influence of Calcium-Sensing Receptor Gene on Urinary Calcium Excretion in Stone-Forming Patients J. Am. Soc. Nephrol., October 1, 2002; 13(10): 2517 - 2523. [Abstract] [Full Text] [PDF]

				M. Dijkgraaf-ten Bolscher, J. C. Netelenbos, R. Barto, and W. J.F. van der Vijgh Strontium as a Marker for Intestinal Calcium Absorption: The Stimulatory Effect of Calcitriol Clin. Chem., February 1, 2000; 46(2): 248 - 251. [Abstract] [Full Text] [PDF]

				J.-B. Peng, X.-Z. Chen, U. V. Berger, P. M. Vassilev, H. Tsukaguchi, E. M. Brown, and M. A. Hediger Molecular Cloning and Characterization of a Channel-like Transporter Mediating Intestinal Calcium Absorption J. Biol. Chem., August 6, 1999; 274(32): 22739 - 22746. [Abstract] [Full Text] [PDF]

				R. P. Heaney Absorbing Calcium Clin. Chem., February 1, 1999; 45(2): 161 - 162. [Full Text] [PDF]