Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 45: 616-618, 1999;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (39)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kaplan, I. V.
Right arrow Articles by Levinson, S. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaplan, I. V.
Right arrow Articles by Levinson, S. S.
Related Collections
Right arrow Clinical Immunology
(Clinical Chemistry. 1999;45:616-618.)
© 1999 American Association for Clinical Chemistry, Inc.

Opinion

When Is a Heterophile Antibody Not a Heterophile Antibody? When It Is an Antibody against a Specific Immunogen

Irina V. Kaplan1 and Stanley S. Levinson1,2,a

1 Department of Pathology, and Laboratory Medicine, University of Louisville, Louisville, KY 40292

2 Laboratory Service, Veterans Affairs Medical Center, 800 Zorn Ave., Louisville, KY 40206-1466
a Author for correspondence. Fax 502-894-6265; e-mail levinson{at}louisville.edu

Heterophile antibodies are antibodies produced against poorly defined antigens. These are generally weak antibodies with multispecific activities. Human anti-animal antibodies that develop as a result of treatments with animal immunoglobulins are antibodies with strong avidities, produced against well-defined antigens. Although heterophile antibodies and human anti-animal antibodies interfere with immunological assays by similar mechanisms, modes for identifying the sources of the antibodies and for circumventing or retarding the interference may differ. Unfortunately, there has not been a well-organized attempt to encourage correct definition of these antibodies. This problem of inexact definition is highlighted by recent articles in this Journal. In the present discussion, we examine the history leading to this problem and discuss the origins and the reasons that the nature of the antibody is important for rectifying the problem. We propose a simple nomenclature for general usage that should appropriately characterize these antibodies in most cases.© 1999 American Association for Clinical Chemistry




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
M. D. Kellogg, T. C. Law, S. Huang, and N. Rifai
A Girl with Goiter and Inappropriate Thyroid-Stimulating Hormone Secretion
Clin. Chem., July 1, 2008; 54(7): 1241 - 1244.
[Full Text] [PDF]

Home page
 Ann Rheum DisHome page
W. Hueber, B. H Tomooka, X. Zhao, B. A Kidd, J. W Drijfhout, J. F Fries, W. J van Venrooij, A. L Metzger, M. C Genovese, and W. H Robinson
Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines
Ann Rheum Dis, June 1, 2007; 66(6): 712 - 719.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Y. Liu, A. M. Xydakis, R. C. Hoogeveen, P. H. Jones, E. O. Smith, K. W. Nelson, and C. M. Ballantyne
Multiplexed Analysis of Biomarkers Related to Obesity and the Metabolic Syndrome in Human Plasma, Using the Luminex-100 System
Clin. Chem., July 1, 2005; 51(7): 1102 - 1109.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
D. J. Warren, J. Bjerner, E. Paus, O. P. Bormer, and K. Nustad
Use of an In Vivo Biotinylated Single-Chain Antibody as Capture Reagent in an Immunometric Assay to Decrease the Incidence of Interference from Heterophilic Antibodies
Clin. Chem., May 1, 2005; 51(5): 830 - 838.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
J. Kamblock, L. Payot, B. Iung, P. Costes, T. Gillet, C. Le Goanvic, P. Lionet, B. Pagis, J. Pasche, C. Roy, et al.
Does rheumatic myocarditis really exists? Systematic study with echocardiography and cardiac troponin I blood levels
Eur. Heart J., May 1, 2003; 24(9): 855 - 862.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
V. Marks
False-Positive Immunoassay Results: A Multicenter Survey of Erroneous Immunoassay Results from Assays of 74 Analytes in 10 Donors from 66 Laboratories in Seven Countries
Clin. Chem., November 1, 2002; 48(11): 2008 - 2016.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
J. Bjerner, K. Nustad, L. F. Norum, K. H. Olsen, and O. P. Bormer
Immunometric Assay Interference: Incidence and Prevention
Clin. Chem., April 1, 2002; 48(4): 613 - 621.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. S. Jaffe, J. Ravkilde, R. Roberts, U. Naslund, F. S. Apple, M. Galvani, and H. Katus
It's Time for a Change to a Troponin Standard
Circulation, September 12, 2000; 102(11): 1216 - 1220.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. W. Butch
Falsely Increased Values for Rabbit Immunoglobulin-based Nephelometric Immunoassays Attributable to Human Anti-Rabbit Antibodies
Clin. Chem., August 1, 2000; 46(8): 1207 - 1208.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. Revelen, A. Bordron, M. Dueymes, P. Youinou, and J. Arvieux
False Positivity in a Cyto-ELISA for Anti-Endothelial Cell Antibodies Caused by Heterophile Antibodies to Bovine Serum Proteins
Clin. Chem., February 1, 2000; 46(2): 273 - 278.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
K. D. Onuska and S. A. Hill
Effect of Rheumatoid Factor on Cardiac Troponin I Measurement Using Two Commercial Measurement Systems
Clin. Chem., February 1, 2000; 46(2): 307 - 308.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. J. Frost, S. S. Levinson, and I. V. Kaplan
More on Heterophile and Human Anti-Animal Antibodies • The authors of the article cited above reply:
Clin. Chem., November 1, 1999; 45(11): 2042 - 2043.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the American Association for Clinical Chemistry.