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The Lipoprotein Lipase HindIII Polymorphism: Association with Total Cholesterol and LDL-Cholesterol, but not with HDL and Triglycerides in 342 Females

¹ Medizinische Klinik III, Universität Heidelberg, 69115 Heidelberg, Germany.

² US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111.

³ Abteilung Klinische Chemie, Universität Freiburg, 79106 Freiburg, Germany.
^a Address correspondence to this author at: Universität Heidelberg, Innere Medizin III, Bergheimer Strasse 58, 69115 Heidelberg, Germany. Fax 49-6221-565515; e-mail jkreuzer{at}med.uni-heidelberg.de

Background: Lipoprotein lipase (LPL) is the rate-limiting enzyme in the hydrolysis of core triglycerides in chylomicrons and VLDL.

Methods: We investigated the association between the HindIII polymorphism of the LPL gene and fasting glucose, lipid, and lipoprotein concentrations in 683 Caucasians. We first stabilized the study subjects, using an 8-day diet and exercise intervention program before obtaining blood samples. The use of this standardization period reduced the variance of all glucose and lipid concentrations.

Results: In our study, the HindIII allele frequencies for females and males were 0.29 and 0.34 for H- and 0.71 and 0.66 for H+, respectively. We found in females, but not in males, a significant association between the HindIII genotype and total cholesterol (P = 0.007) and LDL-cholesterol (P = 0.018), with females homozygous for the rare H- allele having the lowest, heterozygotes (H-/+) having intermediate, and women homozygous for the common H+ allele having the highest of each of these lipid traits. With regard to triglycerides, HDL-cholesterol, and glucose, no significant effect of the HindIII genotype was noted in either gender.

Conclusions: These results suggest that in a gender-specific manner, the rare LPL HindIII H- allele has a cholesterol-lowering and, therefore, potentially cardioprotective effect compared with the common H+ allele. © 1999 American Association for Clinical Chemistry

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