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Clinical Chemistry 45: 1377-1383, 1999;
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(Clinical Chemistry. 1999;45:1377-1383.)
© 1999 American Association for Clinical Chemistry, Inc.

Articles

Clinical Perspectives in the Diagnosis of Thyroid Disease

Michael M. Kaplan

Associated Endocrinologists, 6900 Orchard Lake Road, Suite 203, West Bloomfield, MI 48322, and Departments of Medicine and Nuclear Medicine, William Beaumont Hospital, Royal Oak, MI 48073. Fax 248-855-5628; e-mail mmkallegro{at}aol.com

Background: The wide array of available thyroid diagnostic tests can help provide accurate diagnoses for most cases of thyroid disease but can be confusing and costly when used inappropriately.

Methods: Published articles were reviewed and combined with the author's clinical experience and data collected from patients.

Results: The discussions focus on confusing aspects of thyroid diagnostic tests, the use and limitations of the thyrotropin test to screen for thyroid dysfunction, biological factors that complicate the interpretation of this and other thyroid diagnostic tests, and a combined clinical and laboratory approach to (a) thyroid diseases with only one important dimension ("simplex" conditions) and (b) thyroid diseases with several important dimensions ("multiplex" conditions).

Conclusion: The optimal use of thyroid diagnostic tests is patient-specific and depends on the patient's specific thyroid disease, the stage of disease, and coexisting medical conditions.© 1999 American Association for Clinical Chemistry






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Copyright © 1999 by the American Association for Clinical Chemistry.