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Clinical Chemistry 45: 1543-1547, 1999;
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(Clinical Chemistry. 1999;45:1543-1547.)
© 1999 American Association for Clinical Chemistry, Inc.

Articles

Preanalytical Factors (Biological Variation) and the Measurement of Serum Soluble Intercellular Adhesion Molecule-1 in Humans: Influence of the Time of Day, Food Intake, and Physical and Psychological Stress

Benoit Duguéa, Esa Leppänen and Ralph Gräsbeck

a Author for correspondence. Fax 358-9-4771025.

Background: Adhesion proteins such as soluble intercellular adhesion molecule-1 (sICAM-1) may be important markers for early atherosclerosis and some other diseases. To devise optimum specimen collection procedures, we investigated the effects on serum sICAM-1 of several preanalytical factors (factors that occur before a specimen is analyzed) such as the time of the day, food ingestion, and physical and psychological stress.

Methods: Three sets of experiments were conducted: (a) 30 subjects were investigated during the morning, after an overnight fast, and then after the usual breakfast and at 1200; (b) 20 subjects were studied before and after exposure to thermal stress (sauna + swimming in ice-cold water); and (c) 15 volunteers were investigated after their driving license examination and during a (stress-free) control session. Conventional methods and kits were used to determine the blood picture and serum sICAM-1.

Results: All of these preanalytical factors induced a significant increase (~10%) in the concentration of sICAM-1.

Conclusion: It is advisable to consider timing, food intake, and stress when collecting specimens and analyzing data on the concentration of sICAM-1 in serum.






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Copyright © 1999 by the American Association for Clinical Chemistry.