Clinical Chemistry
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Clinical Chemistry 45: 1587-1595, 1999;
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(Clinical Chemistry. 1999;45:1587-1595.)
© 1999 American Association for Clinical Chemistry, Inc.

Articles

Advances in Photoacoustic Noninvasive Glucose Testing

Hugh A. MacKenzie1,a, Helen S. Ashton1, Stephen Spiers1, Yaochun Shen1, Scott S. Freeborn1, John Hannigan1, John Lindberg1 and Peter Rae2

1 Department of Physics, Heriot-Watt University, Riccarton, Edinburgh EH14 4AS, Scotland.

2 Department of Clinical Biochemistry, Western General Hospital, Edinburgh EH4 2XU, Scotland.
a Author for correspondence. Fax 44 131 451 3136; e-mail H.A.MacKenzie{at}hw.ac.uk

We report here on in vitro and in vivo experiments that are intended to explore the feasibility of photoacoustic spectroscopy as a tool for the noninvasive measurement of blood glucose. The in vivo results from oral glucose tests on eight subjects showed good correlation with clinical measurements but indicated that physiological factors and person-to-person variability are important. In vitro measurements showed that the sensitivity of the glucose measurement is unaffected by the presence of common blood analytes but that there can be substantial shifts in baseline values. The results indicate the need for spectroscopic data to develop algorithms for the detection of glucose in the presence of other analytes.




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