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Clinical Chemistry 46: 18-23, 2000;
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(Clinical Chemistry. 2000;46:18-23.)
© 2000 American Association for Clinical Chemistry, Inc.

Articles

Genetic Analysis of the CYP2D6 Locus in a Hong Kong Chinese Population

Mercè Garcia-Barceló1,a, Lok Yee Chow1, Helen Fung Kum Chiu1, Yun Kowk Wing1, Dominic Tak Shing Lee1, Kwok Lim Lam1 and Mary Miu Yee Waye2

1 Department of Psychiatry, 11/F Room 134046, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

2 Department of Biochemistry, Room 608, 6/F Mong Man Wai Building, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
a Author for correspondence. Fax 852-2646-2284; e-mail b025744{at}mailserv.cuhk.edu.hk

Background: The cytochrome P450 CYP2D6 enzyme debrisoquine 4-hydroxylase metabolizes many different classes of commonly used drugs, such as tricyclic antidepressants and neuroleptics. Genetic polymorphism of the CYP2D6 gene is responsible for pronounced interindividual and interracial differences in the metabolism of these drugs. The CYP2D6*10 allele and its variants are the most frequent alleles found in Orientals, and they are responsible for diminished debrisoquine 4-hydroxylase activity because of the presence of a C188->T mutation in exon 1.

Methods: One hundred nineteen Hong Kong Chinese subjects were genotyped by means of allele-specific PCR, PCR, and restriction enzyme analysis for 10 CYP2D6 alleles (CYP2D6*1, *2, *4D, *5, *8/*14, *10A, *10B, *15, *16, and J9).

Results: CYP2D6*10B was the most prevalent allele, and CYP2D6*10/CYP2D6*10 was the most frequent genotype, representing 46.22% of the population.

Conclusions: There was no significant difference in the prevalence of the alleles analyzed between our study and the Chinese populations genotyped previously. This is the largest study in terms of the number of CYP2D6 alleles analyzed in an Oriental population and the first one conducted in a Hong Kong Chinese population.




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