Clinical Chemistry
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Clinical Chemistry 46: 399-403, 2000;
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(Clinical Chemistry. 2000;46:399-403.)
© 2000 American Association for Clinical Chemistry, Inc.

Articles

Cerebrospinal Fluid Protein Concentrations in Children: Age-related Values in Patients without Disorders of the Central Nervous System

Daniel Bioua, Jean-François Benoist, Claire Nguyen-Thi, Xuan Huong, Philippe Morel and Martine Marchand

a Author for correspondence. Fax: 33-1-40-03-47-90; e-mail daniel.adrbp{at}wanadoo.fr

Background: The published reference values for cerebrospinal fluid (CSF) total protein concentrations in children suffer from two major drawbacks: (a) the age-related range often is too broad when applied to the steeply falling concentrations in early infancy; and (b) no values have been published for widely used dry chemistry methods.

Methods: We conducted a 2-year retrospective survey of CSF results obtained in a children’s hospital with a dry chemistry-based method set up on the Vitros 700 analyzer.

Results: The data related to ambulatory children up to 16 years of age and term neonates with no clinical or biological signs of brain disease (n = 1074). Seven age groups with significantly different CSF protein values were identified, and their age-related percentiles (5th, 50th, and 95th) were determined. On the basis of the upper 95th percentile, from age 0 to 6 months the CSF protein concentrations fell rapidly from 1.08 to 0.40 g/L. A plateau (0.32 g/L) was reached from age 6 months to 10 years, followed by a slight increase (0.41 g/L) in the 10–16 years age range.

Conclusions: These results imply that CSF total protein concentrations in the pediatric setting, particularly in infants, must always be interpreted with regard to narrow age-related reference values to avoid false-positive results.




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Compiled by David E. Bruns, Editor (dbruns@aacc.org)
Clin. Chem., April 1, 2001; 47(4): 797 - 797.
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