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Clinical Chemistry 46: 577-581, 2000;
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(Clinical Chemistry. 2000;46:577-581.)
© 2000 American Association for Clinical Chemistry, Inc.

Articles

Propofol-associated Rhabdomyolysis with Cardiac Involvement in Adults: Chemical and Anatomic Findings

Edward B. Stelow, Vandita P. Johari, Stephen A. Smith, John T. Crosson and Fred S. Applea

Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, Minneapolis, MN 55415.
a Address correspondence to this author at: Hennepin County Medical Center, Clinical Laboratories (812), 701 Park Ave., Minneapolis, MN 55415. Fax 612-904-4229; e-mail fred.apple{at}co.hennepin.mn.us

Propofol, a central-acting sedative agent, has been implicated in the development of rhabdomyolysis in children. We describe two adults who developed rhabdomyolysis after receiving high rates of propofol infusion. Rhabdomyolysis of both skeletal and cardiac muscle was suggested in both patients by marked increases of creatine kinase (>170 000 U/L) and cardiac troponin I (11 and 46 µg/L in patients one and two, respectively). Creatine kinase and cardiac troponin I values were highly correlated in each patent (r = 0.786 and 0.988 in patients one and two, respectively). Autopsy of one patient confirmed the diagnosis of skeletal and cardiac rhabdomyolysis.




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