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Clinical Chemistry 46: 1171-1178, 2000;
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(Clinical Chemistry. 2000;46:1171-1178.)
© 2000 American Association for Clinical Chemistry, Inc.

Articles

Bone Lead Concentrations Assessed by in Vivo X-Ray Fluorescence

Theresa M. Ambrose1, Muhammad Al-Lozi2 and Mitchell G. Scott1,a

Departments of
1 Laboratory Medicine and
2 Neurology, Washington University School of Medicine, 660 S. Euclid St., St. Louis, MO 63110-1093.
a Author for correspondence. Fax 314-362-1461; e-mail mscott{at}pathbox.wustl.edu

The assessment of past chronic lead exposure is difficult. Chronic lead burden is not always correctly assessed using laboratory-based tests that are useful for acute or recent exposures. We describe a case of suspected chronic lead exposure that illustrated the need for improved and possibly noninvasive methods to determine cumulative lead body burden. X-Ray fluorescence (XRF) is discussed as a method to obtain in vivo bone lead measurements. We discuss the potential of such measurements as accurate biomarkers of cumulative exposure and whether XRF can be used for retroactive exposure assessment or to predict risk of future health problems.




The following articles in journals at HighWire Press have cited this article:


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A B Engin, D Tuzun, and G Sahin
Evaluation of pteridine metabolism in battery workers chronically exposed to lead
Human and Experimental Toxicology, July 1, 2006; 25(7): 353 - 359.
[Abstract] [PDF]

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 CMAJHome page
E. Weir
Identifying and managing adverse environmental health effects: a new series
Can. Med. Assoc. J., April 1, 2002; 166(8): 1041 - 1043.
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L. Marshall, E. Weir, A. Abelsohn, and M. D. Sanborn
Identifying and managing adverse environmental health effects: 1. Taking an exposure history
Can. Med. Assoc. J., April 1, 2002; 166(8): 1049 - 1055.
[Abstract] [Full Text] [PDF]


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