Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 46: 1230-1238, 2000;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (20)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Attaelmannan, M.
Right arrow Articles by Levinson, S. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Attaelmannan, M.
Right arrow Articles by Levinson, S. S.
Related Collections
Right arrow Clinical Immunology
Right arrow Arnold O. Beckman Conference
Right arrow Proteomics and Protein Markers
(Clinical Chemistry. 2000;46:1230-1238.)
© 2000 American Association for Clinical Chemistry, Inc.

Articles

Understanding and Identifying Monoclonal Gammopathies

Mohammed Attaelmannan1 and Stanley S. Levinson1,2,a

1 Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY 40292.

2 Department of Veteran Affairs Medical Center, Louisville, KY 40206.
a Address correspondence to this author at: Laboratory Service, VAMC, 800 Zorn Ave., Louisville, KY 40206. Fax 502-894-6265; e-mail levinson{at}louisville.edu

Monoclonal gammopathies reflect conditions in which abnormal amounts of immunoglobulins are produced by a clone that developed from a single pro-B germ cell. The condition may reflect a disease process or be benign. The primary purpose of this review is to emphasize routine clinical laboratory techniques that currently are recommended for use in identifying monoclonal gammopathies from serum and urine. Selection of the preferred technique and correct interpretation often is dependent on an understanding of the immunological basis and clinical sequelae associated with these conditions. For this reason, we first briefly discuss the structure, production, and nature of immunoglobulins, and then describe important features of the associated diseases. Finally, we discuss strengths and weaknesses of the techniques and make reference to current recommendations to facilitate optimal testing. We discuss in detail high-resolution electrophoresis, methods for quantifying immunoglobulins, immunofixation electrophoresis, problems associated with analysis of urine immunoglobulins, and identification of cryoglobulins and immune complexes.




The following articles in journals at HighWire Press have cited this article:


Home page
 BloodHome page
R. L. Comenzo
How I treat amyloidosis
Blood, October 8, 2009; 114(15): 3147 - 3157.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. A. Simons, A. R. Molinelli, K. Sobhani, P. M. Rainey, and A. N. Hoofnagle
Two Cases with Unusual Vancomycin Measurements
Clin. Chem., March 1, 2009; 55(3): 578 - 580.
[Full Text] [PDF]

Home page
 haematolHome page
E. Kastritis, A. Anagnostopoulos, M. Roussou, S. Toumanidis, C. Pamboukas, M. Migkou, A. Tassidou, I. Xilouri, S. Delibasi, E. Psimenou, et al.
Treatment of light chain (AL) amyloidosis with the combination of bortezomib and dexamethasone
Haematologica, October 1, 2007; 92(10): 1351 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. R. Nowrousian, D. Brandhorst, C. Sammet, M. Kellert, R. Daniels, P. Schuett, M. Poser, S. Mueller, P. Ebeling, A. Welt, et al.
Serum Free Light Chain Analysis and Urine Immunofixation Electrophoresis in Patients with Multiple Myeloma
Clin. Cancer Res., December 15, 2005; 11(24): 8706 - 8714.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
C. Gay-Bellile, D. Bengoufa, P. Houze, D. Le Carrer, M. Benlakehal, B. Bousquet, B. Gourmel, and T. Le Bricon
Automated Multicapillary Electrophoresis for Analysis of Human Serum Proteins
Clin. Chem., November 1, 2003; 49(11): 1909 - 1915.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Salomo, P. Gimsing, and L. B. Nielsen
Simple Method for Quantification of Bence Jones Proteins
Clin. Chem., December 1, 2002; 48(12): 2202 - 2207.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
K. Matsuda, N. Hiratsuka, T. Koyama, Y. Kurihara, O. Hotta, Y. Itoh, and K. Shiba
Sensitive Method for Detection and Semiquantification of Bence Jones Protein by Cellulose Acetate Membrane Electrophoresis Using Colloidal Silver Staining
Clin. Chem., April 1, 2001; 47(4): 763 - 766.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the American Association for Clinical Chemistry.