Clinical Chemistry
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Clinical Chemistry 46: 1401-1405, 2000;
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(Clinical Chemistry. 2000;46:1401-1405.)
© 2000 American Association for Clinical Chemistry, Inc.

Articles

Vitamin E and Coronary Heart Disease in Tunisians

Moncef Feki1, Malek Souissi1, Elyes Mokhtar2, Mohamed Hsairi3, Naziha Kaabachi1, Helena Antebi4, Louis Gérald Alcindor4, Rachid Mechmeche2 and Abderraouf Mebazaa1,a

1 Laboratoire de Biochimie Clinique and
2 Service des Explorations Cardiologiques, Hopital La Rabta, Tunis, Tunisia.

3 Institut National de la Santé Publique, Tunis, Tunisia.

4 Laboratoire de Nutrition, Faculté de Medecine, rue des Saints Pères, 75270 Paris Cedex 06, France.
a Address correspondence to this author at: Laboratoire de Biochimie Clinique, Hopital La Rabta, 1007 Eljabbari, Tunis, Tunisie. Fax 21-61-570506; e-mail abderraouf.mebazaa{at}rns.tn

Background: Vitamin E (VE) is thought to be effective in preventing atherosclerosis. However, to date no consistent relationship has been identified between VE and coronary heart disease (CHD). This study was designed to assess the degree of association between VE and CHD in a sample of the Tunisian population.

Methods: Sixty-two angiographically confirmed coronary atherosclerotic patients and 65 age- and sex-matched controls were included. VE was measured in plasma and in the LDL fraction by HPLC. Cholesterol, triglycerides, and phospholipids were measured by enzymatic methods.

Results: A trend toward a meaningful decrease of plasma VE was observed in affected patients compared with controls (P = 0.06). VE concentrations standardized for cholesterol and lipid concentrations were significantly lower (P <0.02) in coronary patients than in controls (4.35 ± 1.03 vs 4.82 ± 1.23 mmol/mol for cholesterol-adjusted VE and 2.35 ± 0.56 vs 2.66 ± 0.65 mmol/mol for lipid-adjusted VE, respectively). In the LDL fraction, only cholesterol-standardized VE was significantly lower in cases than controls (3.84 ± 1.13 vs 4.41 ± 1.16 mmol/mol). This association between VE and CHD remained unchanged independent of age, sex, smoking habit, hypertension, and diabetes. In CHD patients, lower lipid-adjusted VE was associated with enhanced LDL susceptibility to oxidation but without alteration of the serum fatty acid profile.

Conclusions: These results support the hypothesis that VE plays a role in preventing atherosclerosis.




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
M. Haidari, E. Javadi, M. Kadkhodaee, and A. Sanati
Enhanced Susceptibility to Oxidation and Diminished Vitamin E Content of LDL from Patients with Stable Coronary Artery Disease
Clin. Chem., July 1, 2001; 47(7): 1234 - 1240.
[Abstract] [Full Text] [PDF]


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