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Articles |
1-Antitrypsin Deficiency: MZ Individuals with Chronic Obstructive Pulmonary Disease May Have Lower Lung Function Than MM Individuals
1
Department of Clinical Biochemistry, Herlev University Hospital, DK-2730 Herlev, Denmark.
2
Department of Respiratory Medicine, Hvidovre University
Hospital, DK-2650 Hvidovre, Denmark.
3
The Copenhagen City Heart Study, Bispebjerg University
Hospital, DK-2400 Copenhagen NV, Denmark.
a Address correspondence to this author at: Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark. Fax 45-35452524;
at-h{at}rh.dk.
Background: We tested whether intermediate (MZ,
SZ) and severe (ZZ)
1-antitrypsin deficiency affects lung function in the
population at large.
Methods: We performed spirometry [forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC)] and genotyping of 9187 individuals from the adult general population of Copenhagen, Denmark.
Results: As expected, the frequencies of individuals with MM, MS, SS, MZ, SZ, and ZZ genotypes were 0.891, 0.054, 0.001, 0.052, 0.001, and 0.001, respectively. Genotype interacted with clinically established chronic obstructive pulmonary disease (COPD) on the percentage of the predicted FEV1 (P = 0.004): the percentage of the predicted FEV1 was reduced in MZ compared with MM individuals among those with clinically established COPD, but not among those without COPD. Furthermore, SZ compound heterozygotes had lower FEV1/FVC ratios than MM individuals (P <0.05), and ZZ homozygotes had lower percentages of the predicted FEV1 and FEV1/FVC ratios than MM, MS, SS, and MZ individuals (all Ps <0.01). Reduced lung function in SZ and ZZ vs MM individuals could be demonstrated in current and ex-smokers, but not in nonsmokers. Compared with MM individuals in the same groups, FEV1 was reduced 655 mL in MZ individuals with clinically established COPD, 364 mL in SZ current smokers, and 791 mL in ZZ current smokers.
Conclusions: In the population at large, MZ was
associated with reduced pulmonary function in individuals with
clinically established COPD, whereas SZ and
ZZ were associated with reduced pulmonary function in
smokers. The presence of the 1-antitrypsin
MZ genotype may in certain circumstances produce marked
aggravation of airway obstruction in individuals prone to develop
COPD.
The following articles in journals at HighWire Press have cited this article:
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