Clinical Chemistry Siemens Point of Care - Urinalysis
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 47: 418-425, 2001;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Erratum
Right arrow A correction has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (185)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roberts, W. L.
Right arrow Articles by Rifai, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roberts, W. L.
Right arrow Articles by Rifai, N.
Related Collections
Right arrow Clinical Immunology
Right arrow Heart Health and the Clinical Laboratory
Right arrow Endocrinology and Metabolism
(Clinical Chemistry. 2001;47:418-425.)
© 2001 American Association for Clinical Chemistry, Inc.

Articles

Evaluation of Nine Automated High-Sensitivity C-Reactive Protein Methods: Implications for Clinical and Epidemiological Applications. Part 2

William L. Roberts1,a, Linda Moulton2, Terence C. Law3, Genesis Farrow3, Margaret Cooper-Anderson4, John Savory4,5 and Nader Rifai3

1 Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132.

2 ARUP Institute for Experimental and Clinical Pathology, Salt Lake City, UT 84108.

3 Departments of Laboratory Medicine and Pathology, Children’s Hospital and Harvard Medical School, Boston, MA 02115.

4 Departments of Pathology and
5 Biochemistry and Molecular Genetics, University of Virginia Health Science Center, Charlottesville, VA 22908.
a Address correspondence to this author at: c/o ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108. Fax 801-584-5207; e-mail william.roberts{at}arup-lab.com.

Background: C-Reactive protein (CRP) can provide prognostic information about risk of future coronary events in apparently healthy subjects. This application requires higher sensitivity assays than have traditionally been available in the clinical laboratory.

Methods: Nine high-sensitivity CRP (hs-CRP) methods from Dade Behring, Daiichi, Denka Seiken, Diagnostic Products Corporation, Iatron, Kamiya, Olympus, Roche, and Wako were evaluated for limit of detection, linearity, precision, prozone effect, and comparability with samples from 388 apparently healthy individuals.

Results: All methods had limits of detection that were lower than the manufacturers’ claimed limit of quantification except for the Kamiya, Roche, and Wako methods. All methods were linear at 0.3–10 mg/L. The Diagnostic Products Corporation, Kamiya, Olympus, and Wako methods had imprecision (CVs) >10% at 0.15 mg/L. The Iatron, Olympus, and Wako methods demonstrated prozone effects at hs-CRP concentrations of 12, 206, and 117 mg/L, respectively. hs-CRP concentrations demarcating each quartile in a healthy population were method-dependent. Ninety-two to 95% of subjects were classified into the same quartile of hs-CRP established by the Dade Behring method by the Denka Seiken, Diagnostic Products Corporation, Iatron, and Wako methods. In contrast, 68–77% of subjects were classified into the same quartile by the Daiichi, Kamiya, Olympus, and Roche methods. No subject varied by more than one quartile by any method.

Conclusions: Four of the nine examined hs-CRP methods classified apparently healthy subjects into quartiles of hs-CRP similar to the classifications assigned by the comparison method. Additional standardization efforts are required because an individual patient’s results will be interpreted using population-based cutpoints.




The following articles in journals at HighWire Press have cited this article:


Home page
 Eur Heart JHome page
Y. J. Hong, M. H. Jeong, Y. H. Choi, J. S. Ko, M. G. Lee, W. Y. Kang, S. E. Lee, S. H. Kim, K. H. Park, D. S. Sim, et al.
Impact of plaque components on no-reflow phenomenon after stent deployment in patients with acute coronary syndrome: a virtual histology-intravascular ultrasound analysis
Eur. Heart J., February 19, 2009; (2009) ehp034v1.
[Abstract] [Full Text] [PDF]

Home page
 ANGIOLOGYHome page
M. Bo, L. Corsinovi, A. Brescianini, A. Sona, M. Astengo, R. Dumitrache, M. F. Ferrio, L. Pricop, and G. Fonte
High-Sensitivity C-Reactive Protein Is Not Independently Associated With Peripheral Subclinical Atherosclerosis
Angiology, February 1, 2009; 60(1): 12 - 20.
[Abstract] [PDF]

Home page
 Clin. Chem.Home page
T. Shemesh, K. G. Rowley, A. J. Jenkins, J. D. Best, and K. O'Dea
C-Reactive Protein Concentrations Are Very High and More Stable over Time Than the Traditional Vascular Risk Factors Total Cholesterol and Systolic Blood Pressure in an Australian Aboriginal Cohort
Clin. Chem., February 1, 2009; 55(2): 336 - 341.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
B. M. Scirica, C. P. Cannon, M. S. Sabatine, P. Jarolim, S. Sloane, N. Rifai, E. Braunwald, D. A. Morrow, and for the PROVE IT-TIMI 22 Investigators
Concentrations of C-Reactive Protein and B-Type Natriuretic Peptide 30 Days after Acute Coronary Syndromes Independently Predict Hospitalization for Heart Failure and Cardiovascular Death
Clin. Chem., February 1, 2009; 55(2): 265 - 273.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
P. M Ridker
C-Reactive Protein: Eighty Years from Discovery to Emergence as a Major Risk Marker for Cardiovascular Disease
Clin. Chem., February 1, 2009; 55(2): 209 - 215.
[Full Text] [PDF]

Home page
 StrokeHome page
V. Nambi, R. C. Hoogeveen, L. Chambless, Y. Hu, H. Bang, J. Coresh, H. Ni, E. Boerwinkle, T. Mosley, R. Sharrett, et al.
Lipoprotein-Associated Phospholipase A2 and High-Sensitivity C-Reactive Protein Improve the Stratification of Ischemic Stroke Risk in the Atherosclerosis Risk in Communities (ARIC) Study
Stroke, February 1, 2009; 40(2): 376 - 381.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M Kohler, L Ayers, J C T Pepperell, K L Packwood, B Ferry, N Crosthwaite, S Craig, M M Siccoli, R J O Davies, and J R Stradling
Effects of continuous positive airway pressure on systemic inflammation in patients with moderate to severe obstructive sleep apnoea: a randomised controlled trial
Thorax, January 1, 2009; 64(1): 67 - 73.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. Suk Danik, N. Rifai, J. E. Buring, and P. M. Ridker
Lipoprotein(a), Hormone Replacement Therapy, and Risk of Future Cardiovascular Events
J. Am. Coll. Cardiol., July 8, 2008; 52(2): 124 - 131.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Kelley-Hedgepeth, D. M. Lloyd-Jones, A. Colvin, K. A. Matthews, J. Johnston, M. R. Sowers, B. Sternfeld, R. C. Pasternak, C. U. Chae, and for the SWAN Investigators
Ethnic Differences in C-Reactive Protein Concentrations
Clin. Chem., June 1, 2008; 54(6): 1027 - 1037.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
P. R. Bach, B. W. Davis, D. Loughmiller, J. Oertli, and J. Taylor
C-Reactive Protein (CRP) in Neonates: Comparing VITROS Slide and High-Sensitivity CRP Methods
Clin. Chem., November 1, 2007; 53(11): 1979 - 1981.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. S. Sabatine, D. A. Morrow, M. O'Donoghue, K. A. Jablonksi, M. M. Rice, S. Solomon, Y. Rosenberg, M. J. Domanski, J. Hsia, and for the PEACE Investigators
Prognostic Utility of Lipoprotein-Associated Phospholipase A2 for Cardiovascular Outcomes in Patients With Stable Coronary Artery Disease
Arterioscler. Thromb. Vasc. Biol., November 1, 2007; 27(11): 2463 - 2469.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
T. Wu, W. C. Willett, N. Rifai, and E. B. Rimm
Plasma Fluorescent Oxidation Products as Potential Markers of Oxidative Stress for Epidemiologic Studies
Am. J. Epidemiol., September 1, 2007; 166(5): 552 - 560.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
T. Omland, M. S. Sabatine, K. A. Jablonski, M. M. Rice, J. Hsia, R. Wergeland, S. Landaas, J. L. Rouleau, M. J. Domanski, C. Hall, et al.
Prognostic Value of B-Type Natriuretic Peptides in Patients With Stable Coronary Artery Disease: The PEACE Trial
J. Am. Coll. Cardiol., July 17, 2007; 50(3): 205 - 214.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
T. Liu, G. Li, L. Li, and P. Korantzopoulos
Association Between C-Reactive Protein and Recurrence of Atrial Fibrillation After Successful Electrical Cardioversion: A Meta-Analysis
J. Am. Coll. Cardiol., April 17, 2007; 49(15): 1642 - 1648.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. S. Sabatine, D. A. Morrow, K. A. Jablonski, M. M. Rice, J. W. Warnica, M. J. Domanski, J. Hsia, B. J. Gersh, N. Rifai, P. M Ridker, et al.
Prognostic Significance of the Centers for Disease Control/American Heart Association High-Sensitivity C-Reactive Protein Cut Points for Cardiovascular and Other Outcomes in Patients With Stable Coronary Artery Disease
Circulation, March 27, 2007; 115(12): 1528 - 1536.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
D. A. Schaumberg, W. G. Christen, J. E. Buring, R. J. Glynn, N. Rifai, and P. M. Ridker
High-Sensitivity C-Reactive Protein, Other Markers of Inflammation, and the Incidence of Macular Degeneration in Women
Arch Ophthalmol, March 1, 2007; 125(3): 300 - 305.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
L. Deutsch
Evaluation of the Effect of Neptune Krill Oil on Chronic Inflammation and Arthritic Symptoms
J. Am. Coll. Nutr., February 1, 2007; 26(1): 39 - 48.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
N. A. Shadick, N. R. Cook, E. W. Karlson, P. M Ridker, N. E. Maher, J. E. Manson, J. E. Buring, and I.-M. Lee
C-Reactive Protein in the Prediction of Rheumatoid Arthritis in Women
Arch Intern Med, December 11, 2006; 166(22): 2490 - 2494.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
B. M. Everett, T. Kurth, J. E. Buring, and P. M. Ridker
The Relative Strength of C-Reactive Protein and Lipid Levels as Determinants of Ischemic Stroke Compared With Coronary Heart Disease in Women
J. Am. Coll. Cardiol., December 5, 2006; 48(11): 2235 - 2242.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. L. Vega, B. Adams-Huet, R. Peshock, D. Willett, B. Shah, and S. M. Grundy
Influence of Body Fat Content and Distribution on Variation in Metabolic Risk
J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4459 - 4466.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
A. Zeka, J. R Sullivan, P. S Vokonas, D. Sparrow, and J. Schwartz
Inflammatory markers and particulate air pollution: characterizing the pathway to disease
Int. J. Epidemiol., October 1, 2006; 35(5): 1347 - 1354.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
J. A. Pasco, M. A. Kotowicz, M. J. Henry, G. C. Nicholson, H. J. Spilsbury, J. D. Box, and H. G. Schneider
High-sensitivity C-reactive protein and fracture risk in elderly women.
JAMA, September 20, 2006; 296(11): 1353 - 1355.
[Full Text] [PDF]

Home page
 JAMAHome page
J. Suk Danik, N. Rifai, J. E. Buring, and P. M Ridker
Lipoprotein(a), measured with an assay independent of apolipoprotein(a) isoform size, and risk of future cardiovascular events among initially healthy women.
JAMA, September 20, 2006; 296(11): 1363 - 1370.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. A. Albert and P. M Ridker
C-Reactive Protein as a Risk Predictor: Do Race/Ethnicity and Gender Make a Difference?
Circulation, August 1, 2006; 114(5): e67 - e74.
[Full Text] [PDF]

Home page
 CirculationHome page
D. A. Morrow, J. A. de Lemos, M. S. Sabatine, S. D. Wiviott, M. A. Blazing, A. Shui, N. Rifai, R. M. Califf, and E. Braunwald
Clinical Relevance of C-Reactive Protein During Follow-Up of Patients With Acute Coronary Syndromes in the Aggrastat-to-Zocor Trial
Circulation, July 25, 2006; 114(4): 281 - 288.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
N. Rifai, C. M. Ballantyne, M. Cushman, D. Levy, and G. L. Myers
Point: High-Sensitivity C-Reactive Protein and Cardiac C-Reactive Protein Assays: Is There a Need to Differentiate?
Clin. Chem., July 1, 2006; 52(7): 1254 - 1256.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
J. V. Callaghan and S. I. Gutman
Counterpoint: food and drug administration guidance for C-reactive protein assays: matching claims with performance data.
Clin. Chem., July 1, 2006; 52(7): 1256 - 1257.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Takemura, H. Matsumoto, A. Niimi, T. Ueda, H. Matsuoka, M. Yamaguchi, M. Jinnai, S. Muro, T. Hirai, Y. Ito, et al.
High sensitivity C-reactive protein in asthma.
Eur. Respir. J., May 1, 2006; 27(5): 908 - 912.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Khera, J. A. de Lemos, R. M. Peshock, H. S. Lo, H. G. Stanek, S. A. Murphy, F. H. Wians Jr, S. M. Grundy, and D. K. McGuire
Relationship Between C-Reactive Protein and Subclinical Atherosclerosis: The Dallas Heart Study
Circulation, January 3, 2006; 113(1): 38 - 43.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
W. Pitiphat, M. W. Gillman, K. J. Joshipura, P. L. Williams, C. W. Douglass, and J. W. Rich-Edwards
Plasma C-Reactive Protein in Early Pregnancy and Preterm Delivery
Am. J. Epidemiol., December 1, 2005; 162(11): 1108 - 1113.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
C. M. Ballantyne, R. C. Hoogeveen, H. Bang, J. Coresh, A. R. Folsom, L. E. Chambless, M. Myerson, K. K. Wu, A. R. Sharrett, and E. Boerwinkle
Lipoprotein-Associated Phospholipase A2, High-Sensitivity C-Reactive Protein, and Risk for Incident Ischemic Stroke in Middle-aged Men and Women in the Atherosclerosis Risk in Communities (ARIC) Study
Arch Intern Med, November 28, 2005; 165(21): 2479 - 2484.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
N. Lamblin, F. Mouquet, B. Hennache, J. Dagorn, S. Susen, C. Bauters, and P. de Groote
High-sensitivity C-reactive protein: potential adjunct for risk stratification in patients with stable congestive heart failure
Eur. Heart J., November 1, 2005; 26(21): 2245 - 2250.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. Mittermayer, J. Pleiner, G. Schaller, S. Zorn, K. Namiranian, S. Kapiotis, G. Bartel, M. Wolfrum, M. Brugel, J. Thiery, et al.
Tetrahydrobiopterin corrects Escherichia coli endotoxin-induced endothelial dysfunction
Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1752 - H1757.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Khera, D. K. McGuire, S. A. Murphy, H. G. Stanek, S. R. Das, W. Vongpatanasin, F. H. Wians Jr, S. M. Grundy, and J. A. de Lemos
Race and Gender Differences in C-Reactive Protein Levels
J. Am. Coll. Cardiol., August 2, 2005; 46(3): 464 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. Liu, S. Wang, A. Deb, K. A. Nath, Z. S. Katusic, J. P. McConnell, and N. M. Caplice
Proapoptotic, Antimigratory, Antiproliferative, and Antiangiogenic Effects of Commercial C-Reactive Protein on Various Human Endothelial Cell Types In Vitro: Implications of Contaminating Presence of Sodium Azide in Commercial Preparation
Circ. Res., July 22, 2005; 97(2): 135 - 143.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
P. M Ridker, N. Rifai, N. R. Cook, G. Bradwin, and J. E. Buring
Non-HDL Cholesterol, Apolipoproteins A-I and B100, Standard Lipid Measures, Lipid Ratios, and CRP as Risk Factors for Cardiovascular Disease in Women
JAMA, July 20, 2005; 294(3): 326 - 333.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. Di Napoli, M. Schwaninger, R. Cappelli, E. Ceccarelli, G. Di Gianfilippo, C. Donati, H. C.A. Emsley, S. Forconi, S. J. Hopkins, L. Masotti, et al.
Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke: A Statement for Health Care Professionals From the CRP Pooling Project Members
Stroke, June 1, 2005; 36(6): 1316 - 1329.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
H. Hakonarson, S. Thorvaldsson, A. Helgadottir, D. Gudbjartsson, F. Zink, M. Andresdottir, A. Manolescu, D. O. Arnar, K. Andersen, A. Sigurdsson, et al.
Effects of a 5-Lipoxygenase-Activating Protein Inhibitor on Biomarkers Associated With Risk of Myocardial Infarction: A Randomized Trial
JAMA, May 11, 2005; 293(18): 2245 - 2256.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
G. L. Myers, N. Rifai, R. P. Tracy, W. L. Roberts, R. W. Alexander, L. M. Biasucci, J. D. Catravas, T. G. Cole, G. R. Cooper, B. V. Khan, et al.
CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: Report From the Laboratory Science Discussion Group
Circulation, December 21, 2004; 110(25): e545 - e549.
[Full Text] [PDF]

Home page
 CirculationHome page
W. L. Roberts
CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: Laboratory Tests Available to Assess Inflammation--Performance and Standardization: A Background Paper
Circulation, December 21, 2004; 110(25): e572 - e576.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. Rej
Clinical Chemistry through Clinical Chemistry: A Journal Timeline
Clin. Chem., December 1, 2004; 50(12): 2415 - 2458.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
K. D. Monahan, T. E. Wilson, and C. A. Ray
Omega-3 Fatty Acid Supplementation Augments Sympathetic Nerve Activity Responses to Physiological Stressors in Humans
Hypertension, November 1, 2004; 44(5): 732 - 738.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. Fliser, K. Buchholz, H. Haller, and for the EUropean Trial on Olmesartan and Pravastat
Antiinflammatory Effects of Angiotensin II Subtype 1 Receptor Blockade in Hypertensive Patients With Microinflammation
Circulation, August 31, 2004; 110(9): 1103 - 1107.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
B. Schieffer, C. Bunte, J. Witte, K. Hoeper, R. H. Boger, E. Schwedhelm, and H. Drexler
Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease
J. Am. Coll. Cardiol., July 21, 2004; 44(2): 362 - 368.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. Danesh, J. G. Wheeler, G. M. Hirschfield, S. Eda, G. Eiriksdottir, A. Rumley, G. D.O. Lowe, M. B. Pepys, and V. Gudnason
C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease
N. Engl. J. Med., April 1, 2004; 350(14): 1387 - 1397.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. M. Ballantyne, R. C. Hoogeveen, H. Bang, J. Coresh, A. R. Folsom, G. Heiss, and A. R. Sharrett
Lipoprotein-Associated Phospholipase A2, High-Sensitivity C-Reactive Protein, and Risk for Incident Coronary Heart Disease in Middle-Aged Men and Women in the Atherosclerosis Risk in Communities (ARIC) Study
Circulation, February 24, 2004; 109(7): 837 - 842.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
C. Chiesa, A. Panero, J. F. Osborn, A. F. Simonetti, and L. Pacifico
Diagnosis of Neonatal Sepsis: A Clinical and Laboratory Challenge
Clin. Chem., February 1, 2004; 50(2): 279 - 287.
[Full Text] [PDF]

Home page
 CirculationHome page
G. J. Blake, N. Rifai, J. E. Buring, and P. M Ridker
Blood Pressure, C-Reactive Protein, and Risk of Future Cardiovascular Events
Circulation, December 16, 2003; 108(24): 2993 - 2999.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
N. Khuseyinova, A. Imhof, G. Trischler, D. Rothenbacher, W. L. Hutchinson, M. B. Pepys, and W. Koenig
Determination of C-Reactive Protein: Comparison of Three High-Sensitivity Immunoassays
Clin. Chem., October 1, 2003; 49(10): 1691 - 1695.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
T. B. Ledue and N. Rifai
Preanalytic and Analytic Sources of Variations in C-reactive Protein Measurement: Implications for Cardiovascular Disease Risk Assessment
Clin. Chem., August 1, 2003; 49(8): 1258 - 1271.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
E. S. Ford, W. H. Giles, G. L. Myers, N. Rifai, P. M. Ridker, and D. M. Mannino
C-reactive Protein Concentration Distribution among US Children and Young Adults: Findings from the National Health and Nutrition Examination Survey, 1999-2000
Clin. Chem., August 1, 2003; 49(8): 1353 - 1357.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. A. Albert, R. J. Glynn, and P. M Ridker
Plasma Concentration of C-Reactive Protein and the Calculated Framingham Coronary Heart Disease Risk Score
Circulation, July 15, 2003; 108(2): 161 - 165.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
Y.-C. Tsen, G.-Y. Kao, C.-L. Chang, F.-Y. Lai, C.-H. Huang, S. Ouyang, M.-H. Yu, C.-P. Wang, and Y-N. Chiou
Evaluation and Validation of a Duck IgY Antibody-based Immunoassay for High-Sensitivity C-reactive Protein: Avian Antibody Application in Clinical Diagnostics
Clin. Chem., May 1, 2003; 49(5): 810 - 813.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. M. Kimberly, H. W. Vesper, S. P. Caudill, G. R. Cooper, N. Rifai, F. Dati, and G. L. Myers
Standardization of Immunoassays for Measurement of High-Sensitivity C-reactive Protein. Phase I: Evaluation of Secondary Reference Materials
Clin. Chem., April 1, 2003; 49(4): 611 - 616.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
N. Rifai and P. M. Ridker
Population Distributions of C-reactive Protein in Apparently Healthy Men and Women in the United States: Implication for Clinical Interpretation
Clin. Chem., April 1, 2003; 49(4): 666 - 669.
[Full Text] [PDF]

Home page
 CirculationHome page
P. M Ridker
Clinical Application of C-Reactive Protein for Cardiovascular Disease Detection and Prevention
Circulation, January 28, 2003; 107(3): 363 - 369.
[Full Text] [PDF]

Home page
 CirculationHome page
T. A. Pearson, G. A. Mensah, R. W. Alexander, J. L. Anderson, R. O. Cannon III, M. Criqui, Y. Y. Fadl, S. P. Fortmann, Y. Hong, G. L. Myers, et al.
Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: A Statement for Healthcare Professionals From the Centers for Disease Control and Prevention and the American Heart Association
Circulation, January 28, 2003; 107(3): 499 - 511.
[Full Text] [PDF]

Home page
 CirculationHome page
M. A. Albert, R. J. Glynn, and P. M Ridker
Alcohol Consumption and Plasma Concentration of C-Reactive Protein
Circulation, January 28, 2003; 107(3): 443 - 447.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
P. M. Ridker, N. Rifai, L. Rose, J. E. Buring, and N. R. Cook
Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events
N. Engl. J. Med., November 14, 2002; 347(20): 1557 - 1565.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
J. Middleton
Effect of Analytical Error on the Assessment of Cardiac Risk by the High-Sensitivity C-Reactive Protein and Lipid Screening Model
Clin. Chem., November 1, 2002; 48(11): 1955 - 1962.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
P. Garnero, C. Jamin, C.-L. Benhamou, C. Pelissier, and C. Roux
Effects of tibolone and combined 17{beta}-estradiol and norethisterone acetate on serum C-reactive protein in healthy post-menopausal women: a randomized trial
Hum. Reprod., October 1, 2002; 17(10): 2748 - 2753.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
A. D. Blann, P. M. Ridker, and G. Y.H. Lip
Inflammation, Cell Adhesion Molecules, and Stroke: Tools in Pathophysiology and Epidemiology?
Stroke, September 1, 2002; 33(9): 2141 - 2143.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Ishibashi, Y. Takemura, H. Ishida, K. Watanabe, and T. Kawai
C-Reactive Protein Kinetics in Newborns: Application of a High-Sensitivity Analytic Method in Its Determination
Clin. Chem., July 1, 2002; 48(7): 1103 - 1106.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. Rothkrantz-Kos, M. P.J. Schmitz, O. Bekers, P. P.C.A. Menheere, and M. P. van Dieijen-Visser
High-Sensitivity C-Reactive Protein Methods Examined
Clin. Chem., February 1, 2002; 48(2): 359 - 362.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
G. J. Blake and P. M. Ridker
Novel Clinical Markers of Vascular Wall Inflammation
Circ. Res., October 26, 2001; 89(9): 763 - 771.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. S. Ayash
Re: Europium nanoparticles and time-resolved fluorescence for ultrasensitive detection of prostate-specific antigen.
Clin. Chem., September 1, 2001; 47(9): 1743 - 1744.
[Full Text] [PDF]

Home page
 JAMAHome page
M. A. Albert, E. Danielson, N. Rifai, P. M Ridker, and for the PRINCE Investigators
Effect of Statin Therapy on C-Reactive Protein Levels: The Pravastatin Inflammation/CRP Evaluation (PRINCE): A Randomized Trial and Cohort Study
JAMA, July 4, 2001; 286(1): 64 - 70.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. M. Ridker
High-Sensitivity C-Reactive Protein : Potential Adjunct for Global Risk Assessment in the Primary Prevention of Cardiovascular Disease
Circulation, April 3, 2001; 103(13): 1813 - 1818.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American Association for Clinical Chemistry.