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Clinical Chemistry 47: 444-450, 2001;
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(Clinical Chemistry. 2001;47:444-450.)
© 2001 American Association for Clinical Chemistry, Inc.

Articles

Variability and Classification Accuracy of Serial High-Sensitivity C-Reactive Protein Measurements in Healthy Adults

Ira S. Ockene1,a, Charles E. Matthews3, Nader Rifai4, Paul M. Ridker5, George Reed2 and Edward Stanek6

1 Department of Medicine, Divisions of Cardiovascular Medicine and
2 Preventive and Behavioral Medicine, University of Massachusetts Medical School, 55 Lake Ave. North, Worcester, MA 01655.

3 Department of Epidemiology and Biostatistics, University of South Carolina, School of Public Health, Columbia, SC 29208.

4 Department of Laboratory Medicine, Children’s Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA 02115.

5 Division of Preventive Medicine, Harvard Medical School, Brigham and Women’s Hospital, 900 Commonwealth Ave. East, Boston, MA 02215.

6 Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Arnold House Box 30430, Amherst, MA 01003.
a Author for correspondence. Fax 508-856-4571, email ira.ockene{at}umassmed.edu.

Background: Increased concentrations of high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, are associated with increased risk for coronary heart disease. Because of its relationship to inflammation, hs-CRP has considerable biologic variation. This study was carried out to characterize CRP variation and to compare it to another risk factor, total serum cholesterol.

Methods: One hundred thirteen individuals were scheduled to have five measurements each of hs-CRP and total cholesterol carried out at quarterly intervals over a 1-year period. Variations of hs-CRP and total cholesterol were characterized, and classification accuracy was described and compared for both.

Results: The relative variation was comparable for hs-CRP and total cholesterol. When classified by quartile, 63% of first and second hs-CRP measurements were in agreement; for total cholesterol it was 60%. Ninety percent of hs-CRP measurements were within one quartile of each other. This relationship was not altered by the use of log-transformed hs-CRP data.

Conclusion: hs-CRP has a degree of measurement stability that is similar to that of total cholesterol.




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 CirculationHome page
P. M Ridker
Clinical Application of C-Reactive Protein for Cardiovascular Disease Detection and Prevention
Circulation, January 28, 2003; 107(3): 363 - 369.
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 CirculationHome page
T. A. Pearson, G. A. Mensah, R. W. Alexander, J. L. Anderson, R. O. Cannon III, M. Criqui, Y. Y. Fadl, S. P. Fortmann, Y. Hong, G. L. Myers, et al.
Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: A Statement for Healthcare Professionals From the Centers for Disease Control and Prevention and the American Heart Association
Circulation, January 28, 2003; 107(3): 499 - 511.
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 Clin. Chem.Home page
B. Campbell, R. Flatman, T. Badrick, D. Kanowski, I. S. Ockene, C. E. Matthews, N. Rifai, P. M. Ridker, G. Reed, and E. Stanek
Problems with High-Sensitivity C-Reactive Protein * The authors of the article discussed in the above letter respond:
Clin. Chem., January 1, 2003; 49(1): 201 - 202.
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 NEJMHome page
P. M. Ridker, N. Rifai, L. Rose, J. E. Buring, and N. R. Cook
Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events
N. Engl. J. Med., November 14, 2002; 347(20): 1557 - 1565.
[Abstract] [Full Text] [PDF]

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 JAMAHome page
A. D. Pradhan, J. E. Manson, J. E. Rossouw, D. S. Siscovick, C. P. Mouton, N. Rifai, R. B. Wallace, R. D. Jackson, M. B. Pettinger, and P. M Ridker
Inflammatory Biomarkers, Hormone Replacement Therapy, and Incident Coronary Heart Disease: Prospective Analysis From the Women's Health Initiative Observational Study
JAMA, August 28, 2002; 288(8): 980 - 987.
[Abstract] [Full Text] [PDF]

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 CirculationHome page
D. L. Bhatt and E. J. Topol
Need to Test the Arterial Inflammation Hypothesis
Circulation, July 2, 2002; 106(1): 136 - 140.
[Full Text] [PDF]

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 Eur Heart JHome page
W.F. Riesen, H. Engler, M. Risch, W. Korte, and G. Noseda
Short-term effects of atorvastatin on C-reactive protein
Eur. Heart J., May 2, 2002; 23(10): 794 - 799.
[Abstract] [Full Text] [PDF]

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 Arch Intern MedHome page
I. Kushner and A. R. Sehgal
Is High-Sensitivity C-Reactive Protein an Effective Screening Test for Cardiovascular Risk?
Arch Intern Med, April 22, 2002; 162(8): 867 - 869.
[Abstract] [Full Text] [PDF]

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 Cardiovasc ResHome page
M. A Vickers, F. R Green, C. Terry, B. M Mayosi, C. Julier, M. Lathrop, P. J Ratcliffe, H. C Watkins, and B. Keavney
Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein
Cardiovasc Res, March 1, 2002; 53(4): 1029 - 1034.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
S. Rothkrantz-Kos, M. P.J. Schmitz, O. Bekers, P. P.C.A. Menheere, and M. P. van Dieijen-Visser
High-Sensitivity C-Reactive Protein Methods Examined
Clin. Chem., February 1, 2002; 48(2): 359 - 362.
[Full Text] [PDF]

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 Circ. Res.Home page
G. J. Blake and P. M. Ridker
Novel Clinical Markers of Vascular Wall Inflammation
Circ. Res., October 26, 2001; 89(9): 763 - 771.
[Abstract] [Full Text] [PDF]

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 JAMAHome page
A. D. Pradhan, J. E. Manson, N. Rifai, J. E. Buring, and P. M. Ridker
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
JAMA, July 18, 2001; 286(3): 327 - 334.
[Abstract] [Full Text] [PDF]

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 CirculationHome page
P. M. Ridker
High-Sensitivity C-Reactive Protein : Potential Adjunct for Global Risk Assessment in the Primary Prevention of Cardiovascular Disease
Circulation, April 3, 2001; 103(13): 1813 - 1818.
[Abstract] [Full Text] [PDF]


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