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Articles |
1
Department of Laboratory Medicine and
2
Central Laboratory for Ultrastructure Research, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu City 431-3192, Japan.
3
Materials Technology Research Laboratories and
4
Diagnostics Research Laboratories, Daiichi Pure
Chemicals Co., Ibaraki 301-0852, Japan.
aAuthor for correspondence. Fax 81-53-435-2794; e-mail akikondo{at}hama-med.ac.jp.
Background: Hypertriglyceridemia is associated with decreased HDL-cholesterol (HDL-C) and increased small dense LDL. In addition, small dense LDL is known to be susceptible to oxidation.
Methods: We measured LDL particle size, using gradient gel electrophoresis, and malondialdehyde-modified LDL (MDA-LDL), using an ELISA, and investigated the association between triglyceride (TG) concentrations, LDL size, and MDA-LDL.
Results: TG concentrations correlated negatively with the
predominant LDL size (r = -0.650) and HDL-C
concentration (r = -0.556). The relationship
between TG concentration and LDL size, evaluated by measuring MDA-LDL,
distinguished subgroups derived from four subfractions of TG
concentrations and four distribution ranges of LDL size. These
experiments indicated that there is a threshold for oxidation
susceptibility at an LDL size of 25.5 nm and a TG concentration of 1500
mg/L. To investigate the relationship between LDL size, MDA-LDL
concentration, and other lipids (TGs, HDL-C, apolipoprotein B, and
total cholesterol), we evaluated them in control subjects and patients
with diabetes mellitus or hypertriglyceridemia. When the size range for
normal LDL was postulated to be 25.5 
(LDL diameter) < 26.5
nm, the MDA-LDL concentration was significantly higher in the subgroups
of patients with LDL in the size range 24.5 < 25.5 nm
compared with patients with normal LDL. This result also suggests that
the threshold is at a LDL size of 25.5 nm.
Conclusion: The threshold for oxidation susceptibility coincided with the point of LDL size separation between the LDL subclass patterns A and B as an atherosclerotic risk.
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