| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Articles |
1
National Research Council, 00161 Rome, Italy.
2
Institute of Pediatrics, La Sapienza University of Rome, 00161 Rome, Italy.
3
Institute of Hygiene, La Sapienza University of Rome, 00161 Rome, Italy.
4
Division of Obstetrics, S. Camillo Hospital, 00152 Rome, Italy. \ %
5
Division of Neonatology, S. Camillo Hospital, 00152 Rome, Italy.
aAddress correspondence to this author at: Institute of Pediatrics, La Sapienza University of Rome, Viale Regina Elena, 324 00161 Rome, Italy. Fax 39-06-49-218-480; e-mail Claudio.Chiesa{at}Uniroma1.it.
Background: There is a wide range of reported sensitivities and specificities for C-reactive protein (CRP) and interleukin-6 (IL-6) in the detection of early-onset neonatal infection. This prompted us to assess reference intervals for CRP and IL-6 during the 48-h period immediately after birth and to identify maternal and perinatal factors that may affect them.
Methods: CRP and IL-6 values were prospectively obtained for 148 healthy babies (113 term, 35 near-term) at birth and at 24 and 48 h of life, and from their mothers at delivery.
Results: Upper reference limits for CRP at each neonatal age were
established. At birth, CRP was significantly lower than at 24 and
48 h of life. Rupture of membranes 
18 h, perinatal distress, and
gestational hypertension significantly affected the neonatal CRP
dynamics, but at specific ages. There was no correlation between CRP
concentrations in mothers and their offspring at birth. The IL-6 values
observed in the delivering mothers and in their babies at all three
neonatal ages were negatively associated with gestational age. In the
immediate postnatal period, IL-6 dynamics for term babies were
significantly different from those for near-term babies. Maternal IL-6
concentrations correlated with babies’ IL-6 concentrations only for
term deliveries. Apgar score had a significant effect on babies’ IL-6
values at birth.
Conclusions: The patterns of CRP and IL-6 responses in the healthy neonate should be taken into account to optimize their use in the diagnosis of early-onset neonatal sepsis.
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  E K Chung, R L Miller, M T Wilson, S J McGeady, and J F Culhane Antenatal risk factors, cytokines and the development of atopic disease in early childhood Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2007; 92(1): F68 - F73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kaufman and K. D. Fairchild Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants Clin. Microbiol. Rev., July 1, 2004; 17(3): 638 - 680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Chiesa, A. Panero, J. F. Osborn, A. F. Simonetti, and L. Pacifico Diagnosis of Neonatal Sepsis: A Clinical and Laboratory Challenge Clin. Chem., February 1, 2004; 50(2): 279 - 287. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Madan, M. M. Adams, and A. G. S. Philip Frequency and Timing of Symptoms in Infants Screened for Sepsis: Effectiveness of a Sepsis-Screening Pathway Clinical Pediatrics, January 1, 2003; 42(1): 11 - 18. [Abstract] [PDF]
|
|
|
|
|
|
C. Chiesa, G. Pellegrini, A. Panero, J. F. Osborn, F. Signore, M. Assumma, and L. Pacifico C-Reactive Protein, Interleukin-6, and Procalcitonin in the Immediate Postnatal Period: Influence of Illness Severity, Risk Status, Antenatal and Perinatal Complications, and Infection Clin. Chem., January 1, 2003; 49(1): 60 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ishibashi, Y. Takemura, H. Ishida, K. Watanabe, and T. Kawai C-Reactive Protein Kinetics in Newborns: Application of a High-Sensitivity Analytic Method in Its Determination Clin. Chem., July 1, 2002; 48(7): 1103 - 1106. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
