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Clinical Chemistry 47: 1234-1240, 2001;
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Right arrow Lipids, Lipoproteins, and Cardiovascular Risk Factors
(Clinical Chemistry. 2001;47:1234-1240.)
© 2001 American Association for Clinical Chemistry, Inc.

Articles

Enhanced Susceptibility to Oxidation and Diminished Vitamin E Content of LDL from Patients with Stable Coronary Artery Disease

Mehran Haidari1a, Ebrahim Javadi2, Mehry Kadkhodaee3 and Arashmidos Sanati4

1 Cardiovascular Research Center, Tehran University of Medical Sciences, Tehran, Iran. Departments of
2 Biochemistry,
3 Physiology, and
4 Cardiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


aAddress correspondence to this author at: McMaster Bldg., Room 4011c, The Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada. Fax 416-813-6257; e-mail mhaidari{at}sickkids.on.ca.

Background: Convincing evidence points to oxidative modification of LDL as an important trigger in a complex chain of events leading to atherosclerosis. We investigated the occurrence of enhanced susceptibility of LDL to oxidation and decreased vitamin E concentration in LDL as additional risk factors promoting atherosclerosis among patients with established coronary artery disease (CAD).

Methods: We examined 132 patients with angiographically confirmed CAD and compared them with 111 healthy control individuals. We measured conjugated diene production to assess susceptibility of LDL to copper-mediated oxidation. Vitamin E content of LDL was measured by HPLC.

Results: The mean lag time of LDL oxidation and LDL {alpha}-tocopherol/LDL-cholesterol ratio were lower in the patients with CAD (55 ± 14 min and 2.4 ± 1.0 mmol/mmol) than in the controls (63 ± 13 min and 2.9 ± 1.1 mmol/mmol; P <0.0001 and <0.001, respectively). Multiple stepwise regression analysis demonstrated the lag time (odds ratio, 1.96; 95% confidence interval, 1.34–2.87; P <0.0001) and concentration of vitamin E in LDL (odds ratio, 1.65; 95% confidence interval, 1.16–2.33; P <0.005) as independent determinants of CAD. Significant inverse Spearman rank correlations were found between lag time (r = -0.285; P <0.001) or concentration of vitamin E in LDL (r = -0.197; P <0.002) and severity of CAD. Lag times were not significantly correlated with serum C-reactive protein or ferritin.

Conclusions: Our data suggest that a short LDL oxidation lag time and a low concentration of vitamin E in LDL might be independent coronary risk factors for stable CAD in Iranian people.




The following articles in journals at HighWire Press have cited this article:


Home page
 Hum Exp ToxicolHome page
M Kadkhodaee and A Gol
The role of nitric oxide in iron-induced rat renal injury
Human and Experimental Toxicology, November 1, 2004; 23(11): 533 - 536.
[Abstract] [PDF]


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