Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 48: 2105-2114, 2002;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bennion, B. J.
Right arrow Articles by Daggett, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bennion, B. J.
Right arrow Articles by Daggett, V.
Related Collections
Right arrow Proteomics and Protein Markers
(Clinical Chemistry. 2002;48:2105-2114.)
© 2002 American Association for Clinical Chemistry, Inc.

Reviews

Protein Conformation and Diagnostic Tests: The Prion Protein

Brian J. Bennion1 and Valerie Daggetta1

1 Department of Medicinal Chemistry, Box 357610, University of Washington, Seattle, WA 98195-7610.

aAuthor for correspondence. E-mail daggett{at}u.washington.edu.

Background: Many clinical diagnostic tests depend on the accurate detection and quantification of proteins and peptides and their functions. Alterations of protein structure, and the resulting consequences on dynamics, can affect the outcome of laboratory tests. These changes can be a result of mutations, other in vivo factors, or even the experimental conditions of the diagnostic test.

Approach: The relationship between protein structure and dynamics and experimentally observable properties used in diagnostic assays are discussed in light of transmissible spongiform encephalopathies, or prion diseases.

Content: This review describes current efforts and possible future directions of prion diagnostic development. Recent advances in therapeutic development are also addressed.

Summary: The intent of the review is to highlight the role of protein dynamics and conformational change in protein-based diagnostics and treatments for prion disease.




The following articles in journals at HighWire Press have cited this article:


Home page
 J. Gen. Virol.Home page
J.-Y. Madec, S. Simon, S. Lezmi, A. Bencsik, J. Grassi, and T. Baron
Abnormal prion protein in genetically resistant sheep from a scrapie-infected flock
J. Gen. Virol., November 1, 2004; 85(11): 3483 - 3486.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Lane, C. J. Stanley, S. Dealler, and S. M. Wilson
Polymeric Ligands with Specificity for Aggregated Prion Proteins
Clin. Chem., October 1, 2003; 49(10): 1774 - 1775.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the American Association for Clinical Chemistry.