| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Reviews |
1 Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20852.
2 Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20852.
3 Department of Biochemistry, The University of Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390.
aAddress correspondence to this author at: Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd., Room EPN 330F, Rockville, MD 20852. Fax 301-402-0816; e-mail ss1a{at}nih.gov.
The emergence of novel technologies allows researchers to facilitate the comprehensive analyses of genomes, transcriptomes, and proteomes in health and disease. The information that is expected from such technologies may soon exert a dramatic change in the pace of cancer research and impact dramatically on the care of cancer patients. These approaches have already demonstrated the power of molecular medicine in discriminating among disease subtypes that are not recognizable by traditional pathologic criteria and in identifying specific genetic events involved in cancer progression. This review covers a selection of advances in the realm of proteomics and its promise for cancer biomarker discovery. It also addresses issues regarding sample preparation and specificity and discusses current challenges that need to be overcome. Finally, the review touches on the efforts of the Early Detection Research Network at the National Cancer Institute in promoting biomarker discovery for translation at the clinical level.
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  F. Wei, P. Patel, W. Liao, K. Chaudhry, L. Zhang, M. Arellano-Garcia, S. Hu, D. Elashoff, H. Zhou, S. Shukla, et al. Electrochemical Sensor for Multiplex Biomarkers Detection Clin. Cancer Res., July 1, 2009; 15(13): 4446 - 4452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-M. Hsu, H. Lee, H.-F. Juan, Y.-Y. Shih, B.-J. Wang, C.-Y. Pan, Y.-M. Jeng, H.-H. Chang, M.-Y. Lu, K.-H. Lin, et al. Identification of GRP75 as an Independent Favorable Prognostic Marker of Neuroblastoma by a Proteomics Analysis Clin. Cancer Res., October 1, 2008; 14(19): 6237 - 6245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Friedman Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver Physiol Rev, January 1, 2008; 88(1): 125 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Rodrigues, J. A. Teixeira, F. L. Schmitt, M. Paulsson, and H. Lindmark-Mansson The Role of Osteopontin in Tumor Progression and Metastasis in Breast Cancer Cancer Epidemiol. Biomarkers Prev., June 1, 2007; 16(6): 1087 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Balabanov, A. Gontarewicz, P. Ziegler, U. Hartmann, W. Kammer, M. Copland, U. Brassat, M. Priemer, I. Hauber, T. Wilhelm, et al. Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach Blood, February 15, 2007; 109(4): 1701 - 1711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nakagawa, S. K. Huang, S. R. Martinez, A. N. Tran, D. Elashoff, X. Ye, R. R. Turner, A. E. Giuliano, and D. S.B. Hoon Proteomic Profiling of Primary Breast Cancer Predicts Axillary Lymph Node Metastasis Cancer Res., December 15, 2006; 66(24): 11825 - 11830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Wang, J. S. Park, J. S. F. Chu, A. Krakowski, K. Luo, D. J. Chen, and S. Li Proteomic Profiling of Bone Marrow Mesenchymal Stem Cells upon Transforming Growth Factor {beta}1 Stimulation J. Biol. Chem., October 15, 2004; 279(42): 43725 - 43734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kinter Toward Broader Inclusion of Liquid Chromatography-Mass Spectrometry in the Clinical Laboratory Clin. Chem., September 1, 2004; 50(9): 1500 - 1502. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hirsch, K. C. Hansen, A. L. Burlingame, and M. A. Matthay Proteomics: current techniques and potential applications to lung disease Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L1 - L23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Hewitt, J. Dear, and R. A. Star Discovery of Protein Biomarkers for Renal Diseases J. Am. Soc. Nephrol., July 1, 2004; 15(7): 1677 - 1689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Beske, J. Guo, J. Li, D. Bassoni, K. Bland, H. Marciniak, M. Zarowitz, V. Temov, I. Ravkin, and S. Goldbard A Novel Encoded Particle Technology that Enables Simultaneous Interrogation of Multiple Cell Types J Biomol Screen, April 1, 2004; 9(3): 173 - 185. [Abstract] [PDF]
|
|
|
|
|
|
J. Koopmann, Z. Zhang, N. White, J. Rosenzweig, N. Fedarko, S. Jagannath, M. I. Canto, C. J. Yeo, D. W. Chan, and M. Goggins Serum Diagnosis of Pancreatic Adenocarcinoma Using Surface-Enhanced Laser Desorption and Ionization Mass Spectrometry Clin. Cancer Res., February 1, 2004; 10(3): 860 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Floyd and T. M. Mcshane Development and Use of Biomarkers in Oncology Drug Development Toxicol Pathol, January 1, 2004; 32(1_suppl): 106 - 115. [Abstract] [PDF]
|
|
|
|
 |
|
 W. Zhu, X. Wang, Y. Ma, M. Rao, J. Glimm, and J. S. Kovach Detection of cancer-specific markers amid massive mass spectral data PNAS, December 9, 2003; 100(25): 14666 - 14671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Sidransky, R. Irizarry, J. A. Califano, X. Li, H. Ren, N. Benoit, and L. Mao Serum Protein MALDI Profiling to Distinguish Upper Aerodigestive Tract Cancer Patients From Control Subjects J Natl Cancer Inst, November 19, 2003; 95(22): 1711 - 1717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. P. Diamandis Proteomic Patterns in Biological Fluids: Do They Represent the Future of Cancer Diagnostics? Clin. Chem., August 1, 2003; 49(8): 1272 - 1275. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
