Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 48: 1198-1205, 2002;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (103)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Diamandis, E. P.
Right arrow Articles by Yousef, G. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Diamandis, E. P.
Right arrow Articles by Yousef, G. M.
Related Collections
Right arrow Molecular Diagnostics and Genetics
Right arrow Proteomics and Protein Markers
Right arrow Cancer Diagnostics (since 2002)
(Clinical Chemistry. 2002;48:1198-1205.)
© 2002 American Association for Clinical Chemistry, Inc.

Reviews

Human Tissue Kallikreins: A Family of New Cancer Biomarkers

Eleftherios P. Diamandisa1 and George M. Yousef1

1 Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5G 1X5 Canada.

aAddress correspondence to this author at: Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario, M5G 1X5 Canada. E-mail ediamandis{at}mtsinai.on.ca.

Kallikreins are a subgroup of the serine protease enzyme family. Until recently, it was thought that the human kallikrein gene family contained only three members. In the past 3 years, the entire human kallikrein gene locus was discovered and found to contain 15 kallikrein genes. Kallikreins are expressed in many tissues, including steroid hormone-producing or hormone-dependent tissues such as the prostate, breast, ovary, and testis. Most, if not all, kallikreins are regulated by steroid hormones in cancer cell lines. There is strong but circumstantial evidence linking kallikreins and cancer. Prostate-specific antigen (PSA; hK3) and, more recently, human glandular kallikrein (hK2) are widely used tumor markers for prostate cancer. Three other kallikreins, hK6, hK10, and hK11, are emerging new serum biomarkers for ovarian and prostate cancer diagnosis and prognosis. Several other kallikreins are differentially expressed at both the mRNA and protein levels in various endocrine-related malignancies, and they have prognostic value. The coexpression of many kallikreins in the same tissues (healthy and malignant) points to the possible involvement of kallikreins in cascade enzymatic pathways. In addition to their diagnostic/prognostic potential, kallikreins may also emerge as attractive targets for therapeutics.




The following articles in journals at HighWire Press have cited this article:


Home page
 Ann OncolHome page
A. Psyrri, P. Kountourakis, A. Scorilas, S. Markakis, R. Camp, D. Kowalski, E. P. Diamandis, and M. A. Dimopoulos
Human tissue kallikrein 7, a novel biomarker for advanced ovarian carcinoma using a novel in situ quantitative method of protein expression
Ann. Onc., July 1, 2008; 19(7): 1271 - 1277.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
H. Zhang, H.-Y. Lin, Q. Yang, H.-X. Wang, K. X. Chai, L.-M. Chen, and C. Zhu
Expression of Prostasin Serine Protease and Protease Nexin-1 (PN-1) in Rhesus Monkey Ovary During Menstrual Cycle and Early Pregnancy
J. Histochem. Cytochem., December 1, 2007; 55(12): 1237 - 1244.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Klucky, R. Mueller, I. Vogt, S. Teurich, B. Hartenstein, K. Breuhahn, C. Flechtenmacher, P. Angel, and J. Hess
Kallikrein 6 Induces E-Cadherin Shedding and Promotes Cell Proliferation, Migration, and Invasion
Cancer Res., September 1, 2007; 67(17): 8198 - 8206.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. W. McIntosh, Y. Liu, C. Drescher, N. Urban, and E. P. Diamandis
Validation and Characterization of Human Kallikrein 11 as a Serum Marker for Diagnosis of Ovarian Carcinoma
Clin. Cancer Res., August 1, 2007; 13(15): 4422 - 4428.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
L. R. Rodrigues, J. A. Teixeira, F. L. Schmitt, M. Paulsson, and H. Lindmark-Mansson
The Role of Osteopontin in Tumor Progression and Metastasis in Breast Cancer
Cancer Epidemiol. Biomarkers Prev., June 1, 2007; 16(6): 1087 - 1097.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Kishibe, Y. Bando, R. Terayama, K. Namikawa, H. Takahashi, Y. Hashimoto, A. Ishida-Yamamoto, Y.-P. Jiang, B. Mitrovic, D. Perez, et al.
Kallikrein 8 Is Involved in Skin Desquamation in Cooperation with Other Kallikreins
J. Biol. Chem., February 23, 2007; 282(8): 5834 - 5841.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
I. Meinhold-Heerlein, D. Bauerschlag, Y. Zhou, L. M. Sapinoso, K. Ching, H. Frierson Jr., K. Brautigam, J. Sehouli, E. Stickeler, D. Konsgen, et al.
An Integrated Clinical-Genomics Approach Identifies a Candidate Multi-Analyte Blood Test for Serous Ovarian Carcinoma
Clin. Cancer Res., January 15, 2007; 13(2): 458 - 466.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
P. Pothacharoen, S. Siriaunkgul, S. Ong-Chai, J. Supabandhu, P. Kumja, C. Wanaphirak, K. Sugahara, T. Hardingham, and P. Kongtawelert
Raised Serum Chondroitin Sulfate Epitope Level in Ovarian Epithelial Cancer
J. Biochem., October 1, 2006; 140(4): 517 - 524.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. H. Slagter, A. Scorilas, L. J.G. Gooren, W. de Ronde, A. Soosaipillai, E. J. Giltay, M. Paliouras, and E. P. Diamandis
Effect of Testosterone Administration on Serum and Urine Kallikrein Concentrations in Female-to-Male Transsexuals
Clin. Chem., August 1, 2006; 52(8): 1546 - 1551.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. H. Slagter, L. J.G. Gooren, W. de Ronde, A. Soosaipillai, A. Scorilas, E. J. Giltay, M. Paliouras, and E. P. Diamandis
Serum and Urine Tissue Kallikrein Concentrations in Male-to-Female Transsexuals Treated with Antiandrogens and Estrogens
Clin. Chem., July 1, 2006; 52(7): 1356 - 1365.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. P. Michael, G. Pampalakis, S. D. Mikolajczyk, J. Malm, G. Sotiropoulou, and E. P. Diamandis
Human Tissue Kallikrein 5 Is a Member of a Proteolytic Cascade Pathway Involved in Seminal Clot Liquefaction and Potentially in Prostate Cancer Progression
J. Biol. Chem., May 5, 2006; 281(18): 12743 - 12750.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Itoh, B. Ding, T. Shishido, N. Lerner-Marmarosh, N. Wang, N. Maekawa, B. C. Berk, Y. Takeishi, C. Yan, B. C. Blaxall, et al.
Role of p90 Ribosomal S6 Kinase-Mediated Prorenin-Converting Enzyme in Ischemic and Diabetic Myocardium
Circulation, April 11, 2006; 113(14): 1787 - 1798.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
M.R. Darling, L. Jackson-Boeters, T.D. Daley, and E.P. Diamandis
Human Kallikrein 6 Expression in Salivary Gland Tumors
J. Histochem. Cytochem., March 1, 2006; 54(3): 337 - 342.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. A. Borgono, T. Kishi, A. Scorilas, N. Harbeck, J. Dorn, B. Schmalfeldt, M. Schmitt, and E. P. Diamandis
Human Kallikrein 8 Protein Is a Favorable Prognostic Marker in Ovarian Cancer
Clin. Cancer Res., March 1, 2006; 12(5): 1487 - 1493.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. Nagahara, K. Mimori, T. Utsunomiya, G. F. Barnard, M. Ohira, K. Hirakawa, and M. Mori
Clinicopathologic and Biological Significance of Kallikrein 6 Overexpression in Human Gastric Cancer
Clin. Cancer Res., October 1, 2005; 11(19): 6800 - 6806.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. D. Santin, E. P. Diamandis, S. Bellone, A. Soosaipillai, S. Cane, M. Palmieri, A. Burnett, J. J. Roman, and S. Pecorelli
Human Kallikrein 6: A New Potential Serum Biomarker for Uterine Serous Papillary Cancer
Clin. Cancer Res., May 1, 2005; 11(9): 3320 - 3325.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. P. Michael, G. Sotiropoulou, G. Pampalakis, A. Magklara, M. Ghosh, G. Wasney, and E. P. Diamandis
Biochemical and Enzymatic Characterization of Human Kallikrein 5 (hK5), a Novel Serine Protease Potentially Involved in Cancer Progression
J. Biol. Chem., April 15, 2005; 280(15): 14628 - 14635.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Ogawa, T. Utsunomiya, K. Mimori, F. Tanaka, H. Inoue, H. Nagahara, S. Murayama, and M. Mori
Clinical Significance of Human Kallikrein Gene 6 Messenger RNA Expression in Colorectal Cancer
Clin. Cancer Res., April 15, 2005; 11(8): 2889 - 2893.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. S. Okerberg, J. Wu, B. Zhang, B. Samii, K. Blackford, D. T. Winn, K. R. Shreder, J. J. Burbaum, and M. P. Patricelli
High-resolution functional proteomics by active-site peptide profiling
PNAS, April 5, 2005; 102(14): 4996 - 5001.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
H. Matsuzaki, H. Kobayashi, T. Yagyu, K. Wakahara, T. Kondo, N. Kurita, H. Sekino, K. Inagaki, M. Suzuki, N. Kanayama, et al.
Plasma Bikunin As a Favorable Prognostic Factor in Ovarian Cancer
J. Clin. Oncol., March 1, 2005; 23(7): 1463 - 1472.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
I. P. Michael, L. Kurlender, N. Memari, G. M. Yousef, D. Du, L. Grass, C. Stephan, K. Jung, and E. P. Diamandis
Intron Retention: A Common Splicing Event within the Human Kallikrein Gene Family
Clin. Chem., March 1, 2005; 51(3): 506 - 515.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y.-C. Chen, G. Pohl, T.-L. Wang, P. J. Morin, B. Risberg, G. B. Kristensen, A. Yu, B. Davidson, and I.-M. Shih
Apolipoprotein E Is Required for Cell Proliferation and Survival in Ovarian Cancer
Cancer Res., January 1, 2005; 65(1): 331 - 337.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Z. Zhang, R. C. Bast Jr., Y. Yu, J. Li, L. J. Sokoll, A. J. Rai, J. M. Rosenzweig, B. Cameron, Y. Y. Wang, X.-Y. Meng, et al.
Three Biomarkers Identified from Serum Proteomic Analysis for the Detection of Early Stage Ovarian Cancer
Cancer Res., August 15, 2004; 64(16): 5882 - 5890.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
E. P. Diamandis
How Are We Going to Discover New Cancer Biomarkers? A Proteomic Approach for Bladder Cancer
Clin. Chem., May 1, 2004; 50(5): 793 - 795.
[Full Text] [PDF]

Home page
 Mol Cancer ResHome page
C. A. Borgono, I. P. Michael, and E. P. Diamandis
Human Tissue Kallikreins: Physiologic Roles and Applications in Cancer
Mol. Cancer Res., May 1, 2004; 2(5): 257 - 280.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Shigemasa, L. Gu, H. Tanimoto, T. J. O'Brien, and K. Ohama
Human Kallikrein Gene 11 (KLK11) mRNA Overexpression Is Associated with Poor Prognosis in Patients with Epithelial Ovarian Cancer
Clin. Cancer Res., April 15, 2004; 10(8): 2766 - 2770.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
E. P. Diamandis
Mass Spectrometry as a Diagnostic and a Cancer Biomarker Discovery Tool: Opportunities and Potential Limitations
Mol. Cell. Proteomics, April 1, 2004; 3(4): 367 - 378.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
T. Kishi, A. Soosaipillai, L. Grass, S. P. Little, E. M. Johnstone, and E. P. Diamandis
Development of an Immunofluorometric Assay and Quantification of Human Kallikrein 7 in Tissue Extracts and Biological Fluids
Clin. Chem., April 1, 2004; 50(4): 709 - 716.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
X. Xie, Z. Luo, K. M. Slawin, and D. M. Spencer
The EZC-Prostate Model: Noninvasive Prostate Imaging in Living Mice
Mol. Endocrinol., March 1, 2004; 18(3): 722 - 732.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. Scorilas, C. A. Borgono, N. Harbeck, J. Dorn, B. Schmalfeldt, M. Schmitt, and E. P. Diamandis
Human Kallikrein 13 Protein in Ovarian Cancer Cytosols: A New Favorable Prognostic Marker
J. Clin. Oncol., February 15, 2004; 22(4): 678 - 685.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. A. Borgono, L. Grass, A. Soosaipillai, G. M. Yousef, C. D. Petraki, D. H. C. Howarth, S. Fracchioli, D. Katsaros, and E. P. Diamandis
Human Kallikrein 14: A New Potential Biomarker for Ovarian and Breast Cancer
Cancer Res., December 15, 2003; 63(24): 9032 - 9041.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. H. Schmaier
The kallikrein-kinin and the renin-angiotensin systems have a multilayered interaction
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2003; 285(1): R1 - R13.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. Hutchinson, L.-Y. Luo, G. M. Yousef, A. Soosaipillai, and E. P. Diamandis
Purification of Human Kallikrein 6 from Biological Fluids and Identification of its Complex with {alpha}1-Antichymotrypsin
Clin. Chem., May 1, 2003; 49(5): 746 - 751.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L.-Y. Luo, D. Katsaros, A. Scorilas, S. Fracchioli, R. Bellino, M. van Gramberen, H. de Bruijn, A. Henrik, U.-H. Stenman, M. Massobrio, et al.
The Serum Concentration of Human Kallikrein 10 Represents a Novel Biomarker for Ovarian Cancer Diagnosis and Prognosis
Cancer Res., February 15, 2003; 63(4): 807 - 811.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the American Association for Clinical Chemistry.