| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Cell Biology Laboratory, Department of Gynecology and Obstetrics, University of Göttingen Medical School, 37075 Göttingen, Germany.
2 Department of Vascular Biology & Angiogenesis Research, Tumor Biology Center, 79106 Freiburg, Germany.
aAddress correspondence to this author at: Department of Vascular Biology & Angiogenesis Research, Tumor Biology Center, Breisacher Strasse 117, D-79106 Freiburg, Germany. Fax 49-761-206-1505; e-mail augustin{at}angiogenese.de.
Background: The present study was aimed at determining whether routine prenatal measurements of circulating soluble intercellular adhesion molecule (sICAM-1; CD54) and soluble vascular cell adhesion molecule (sVCAM-1; CD106) in midgestation have predictive value for the identification of pregnant women destined to develop preeclampsia or other complications of pregnancy during late gestation.
Methods: Plasma sICAM-1 and sVCAM-1 were analyzed between weeks 22 and 29 of gestation in 1543 pregnant women and related to the outcome of pregnancy in a prospective longitudinal study.
Results: Plasma sICAM-1 and sVCAM-1 in uncomplicated pregnancies were normally distributed and varied over a small range (sICAM-1, SD = 22.5%; sVCAM-1, SD = 25.5%). Of all analyzed uncomplicated pregnancies, 54 (3.95%) were identified with concentrations of sICAM-1 or sVCAM-1 above the mean + 2 SD. In contrast, of 177 pregnancies with complications (prevalence, 11.5%), 97 (55%) had sICAM-1 or sVCAM-1 concentrations above the same cutoffs weeks before the onset of disease. The sensitivities of sICAM-1 and sVCAM-1 measurements were 66% for preeclampsia and hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome), 42% for gestational hypertension, 50% for fetal retardation, 46% for preterm labor, 50% for gestational diabetes mellitus, 67% for gestational proteinuria, and 70% for infections during pregnancy. Taken together, routine prenatal sICAM-1 and sVCAM-1 measurements had an overall predictive value of 64%.
Conclusions: Midgestation measurements of circulating sICAM-1 and sVCAM-1 have a high predictive value (area under the curve of combined sICAM-1 and sVCAM-1 measurements determined by ROC analysis, 0.85) and may identify up to 55% of pregnant women who will later develop a severe pregnancy-related complication.
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  R. W. Powers, J. M. Catov, L. M. Bodnar, M. J. Gallaher, K. Y. Lain, and J. M. Roberts Evidence of Endothelial Dysfunction in Preeclampsia and Risk of Adverse Pregnancy Outcome Reproductive Sciences, April 1, 2008; 15(4): 374 - 381. [Abstract] [PDF]
|
|
|
|
 |
|
 Q. Chen, P. R. Stone, L. M.E. McCowan, and L. W. Chamley Phagocytosis of Necrotic but Not Apoptotic Trophoblasts Induces Endothelial Cell Activation Hypertension, January 1, 2006; 47(1): 116 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Lumbreras-Lacarra, J. M. Ramos-Rincon, and I. Hernandez-Aguado Methodology in Diagnostic Laboratory Test Research in Clinical Chemistry and Clinical Chemistry and Laboratory Medicine Clin. Chem., March 1, 2004; 50(3): 530 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Rajashekhar, A. Loganath, A. C. Roy, and Y. C. Wong Expression and Secretion of the Vascular Cell Adhesion Molecule-1 in Human Placenta and Its Decrease in Fetal Growth Restriction Reproductive Sciences, September 1, 2003; 10(6): 352 - 360. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
