Clinical Chemistry
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Clinical Chemistry 49: 1045-1049, 2003; 10.1373/49.7.1045
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(Clinical Chemistry. 2003;49:1045-1049.)
© 2003 American Association for Clinical Chemistry, Inc.

Minireview

Biological Threat Detection via Host Gene Expression Profiling

Baochuan Lin1,a, Maryanne T. Vahey2, Dzung Thach1, David A. Stenger1 and Joseph J. Pancrazio1

1 Center for Bio/Molecular Science & Engineering, Code 6900, Naval Research Laboratory, Washington, DC 20375.

2 Division of Retrovirology, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850.

aAuthor for correspondence. Fax 202-767-9594; e-mail blin{at}cbmse.nrl.navy.mil.


Abstract

With the increased threat posed by biological weapons, detection techniques for biothreat pathogens are critically needed to monitor and assess the severity of the illness once exposure has occurred. Current approaches for detecting biological threats are either time-consuming or highly specific but provide little information regarding pathogenicity. Genotyping of pathogens by PCR provides a fast and definitive means for identifying pathogens, but reliance on pathogen genotypic endpoints has several limitations. Current progress in DNA microarrays technology provides an alternative way to address the issues faced by traditional detection systems through host gene expression profiles of peripheral blood cells. We discuss the advantages and critical issues facing the use of host gene expression profiling for biological threat detection.




The following articles in journals at HighWire Press have cited this article:


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Automated identification of multiple micro-organisms from resequencing DNA microarrays
Nucleic Acids Res., October 6, 2006; 34(18): 5300 - 5311.
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D. V. Lim, J. M. Simpson, E. A. Kearns, and M. F. Kramer
Current and Developing Technologies for Monitoring Agents of Bioterrorism and Biowarfare
Clin. Microbiol. Rev., October 1, 2005; 18(4): 583 - 607.
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