| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Lipids, Lipoproteins, and Cardiovascular Risk Factors |
1 Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, and
2 Unitat de Medicina Preventiva i Salut Pública, Facultat de Medicina, Universitat Rovira i Virgili, Institut de Recerca en Ciències de la Salut, 43201-Reus, Catalonia, Spain.
aAddress correspondence to this author at: Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, C/Sant Joan s/n, 43201-Reus, Catalonia, Spain. Fax 34-977-312569; e-mail jcamps{at}grupsagessa.com.
Background: Paraoxonase may protect lipoproteins and cell membranes from peroxidation, and alterations in the activity of this enzyme have been associated with some chronic diseases. Serum paraoxonase appears to be mainly under genetic control, but some studies suggest that environmental factors may also modulate its activity. The aim of the present study was to investigate whether diet and lifestyle affect serum paraoxonase activity.
Methods: We studied a population-based sample of 388 individuals (194 women and 194 men; age range, 18–75 years) and assessed their daily dietary intake using a 3-day estimated food record. The variables studied included serum paraoxonase activity, paraoxonase polymorphisms at positions 55 and 192, age, gender, smoking status, physical exercise, body mass index, energy consumption, nutrient intake (total lipids, saturated fatty acids, ß-carotenes, vitamins C and E), and serum lipid concentrations.
Results: Multiple linear regression analysis showed that only genetic polymorphisms, serum cholesterol, HDL-cholesterol concentrations, and cigarette smoking were significant predictors of serum paraoxonase activity. HDL-cholesterol concentrations were also related to body mass index, daily energy consumption, and saturated fatty acid intake.
Conclusions: The between-individual variability of serum paraoxonase activity is regulated mainly by genetic determinants. Although HDL-cholesterol and tobacco smoking may contribute to the modulation of this enzyme, the other nutritional and lifestyle factors do not seem to play a significant role.
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  B. Coll, S. Parra, C. Alonso-Villaverde, G. Aragones, M. Montero, J. Camps, J. Joven, and L. Masana The Role of Immunity and Inflammation in the Progression of Atherosclerosis in Patients With HIV Infection Stroke, September 1, 2007; 38(9): 2477 - 2484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sidoti, C. Antognelli, C. Rinaldi, R. D'Angelo, V. Dattola, P. Girlanda, V. Talesa, and A. Amato Glyoxalase I A111E, paraoxonase 1 Q192R and L55M polymorphisms: susceptibility factors of multiple sclerosis? Multiple Sclerosis, May 1, 2007; 13(4): 446 - 453. [Abstract] [PDF]
|
|
|
|
 |
|
 M. M. Murphy, J. Marsillach, J. Camps, J. Fernandez-Ballart, B. Mackness, M. Mackness, N. Ferre, and J. Joven Influence of PON1 Polymorphisms on the Association between Serum Paraoxonase 1 and Homocysteinemia in a General Population. Clin. Chem., April 1, 2006; 52(4): 781 - 782. [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Ansell, K. E. Watson, A. M. Fogelman, M. Navab, and G. C. Fonarow High-Density Lipoprotein Function: Recent Advances J. Am. Coll. Cardiol., November 15, 2005; 46(10): 1792 - 1798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Rainwater, M. C. Mahaney, X. L. Wang, J. Rogers, L. A. Cox, and J. L. VandeBerg Determinants of variation in serum paraoxonase enzyme activity in baboons J. Lipid Res., July 1, 2005; 46(7): 1450 - 1456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Alonso-Villaverde, B. Coll, S. Parra, M. Montero, N. Calvo, M. Tous, J. Joven, and L. Masana Atherosclerosis in Patients Infected With HIV Is Influenced by a Mutant Monocyte Chemoattractant Protein-1 Allele Circulation, October 12, 2004; 110(15): 2204 - 2209. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
