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Clinical Chemistry 5: 405-413, 1959;
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Clinical Chemistry, Vol 5, 405-413, Copyright © 1959 by the American Association for Clinical Chemistry

An Improved Test for Phenylketonuria

Chauncey O. Rupe 1 and Alfred H. Free 1

1 Miles-Ames Research Laboratory, Elkhart, Indiana.

A simple dip-and-read strip test for detection of phenylketonuria is described. This test contains ferric and magnesium ions and an acid buffer. It is called PHENISTIX. When the strip is moistened with urine it gives a gray to blue color with samples which contain phenylpyruvic acid, the intensity being proportional to the concentration of this constituent. A color chart provides for standardization of results and reproducible reports. Comparison of the performance of the test with conventional laboratory procedures has been carried out on over 1900 samples as tests on unknowns. The new test is reliable for the recognition of phenylketonuria and has some advantages over conventional laboratory procedures.

Submitted on December 4, 1958






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Copyright © 1959 by the American Association for Clinical Chemistry.