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Clinical Chemistry 5: 569-574, 1959;
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Clinical Chemistry, Vol 5, 569-574, Copyright © 1959 by the American Association for Clinical Chemistry

A Procedure for the Determination of Cerebro spinal Fluid Total Protein and Gamma Globulin in Neurologic Disorders

N. M. Papadopoulos 1, W. C. Hess 1, D. O'Doherty 1, and J. E. McLane 1

1 Departments of Biological Chemistry and Neurology, Georgetown University Schools of Medicine and Dentistry, Washington, D. C.

A procedure for determinations of both ggr-globulin and total protein is described. Its application for the analysis of samples of cerebrospinal fluid from non-neurologic, multiple sclerosis, and other central nervous system disorders, revealed a characteristically high ratio of ggr-globulin to total protein in multiple sclerosis. These findings suggest that this simple chemical test may be used routinely as an aid in the diagnosis of multiple sclerosis.

Submitted on April 25, 1959






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Copyright © 1959 by the American Association for Clinical Chemistry.