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Clinical Chemistry 50: 195-200, 2004; 10.1373/clinchem.2003.022459
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(Clinical Chemistry. 2004;50:195-200.)
© 2004 American Association for Clinical Chemistry, Inc.

Clinical Immunology

The Interleukin-6 G(-174)C Promoter Polymorphism Does Not Determine Plasma Interleukin-6 Concentrations in Experimental Endotoxemia in Humans

Georg Endler2,1, Claudia Marsik1,2,1, Christian Joukhadar1, Rodrig Marculescu2, Florian Mayr1, Christine Mannhalter2, Oswald F. Wagner2 and Bernd Jilma1,a

Departments of1 Clinical Pharmacology and2 Medical and Chemical Laboratory Diagnostics, Vienna University, Vienna, Austria.

aAddress correspondence to this author at: Clinical Pharmacology, Division of Hematology and Immunology, Vienna University, Waehringer Guertel 18-20, A-1090 Wien, Austria. Fax 43-1-40400-2998; e-mail Bernd.Jilma{at}univie.ac.at.

Background: Interleukin 6 (IL-6) is a pleiotropic cytokine that plays an essential role in the pathogenesis of acute and chronic infections. As the role of the IL-6 G(-174)C polymorphism in determining serum concentrations of IL-6 is controversial, we studied the genotype-specific IL-6 response in a well-standardized model of systemic inflammation.

Methods: A total of 76 healthy young males (age range, 19–35 years) received a single bolus of 2 ng/kg endotoxin [lipopolysaccharide (LPS)] intravenously. Plasma IL-6 was measured by enzyme immunoassay at 0, 2, 6, and 24 h after LPS infusion, and the IL-6 promoter genotype was analyzed by a mutagenic separated PCR assay.

Results: IL-6 increased 300-fold 2 h after LPS challenge and returned almost to normal within 24 h. Neither basal IL-6 nor the IL-6 response to LPS was significantly affected by the IL-6 promoter genotype.

Conclusions: The IL-6 G(-174)C promoter polymorphism does not significantly influence basal concentrations of IL-6 or peak IL-6 in human endotoxemia.




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