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Clinical Chemistry 51: 2415-2418, 2005. First published September 22, 2005; 10.1373/clinchem.2005.051532
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(Clinical Chemistry. 2005;51:2415-2418.)
© 2005 American Association for Clinical Chemistry, Inc.

History

Enzyme Immunoassay (EIA)/Enzyme-Linked Immunosorbent Assay (ELISA)

Rudolf M. Lequin

Diagnostics Consultancy Desk, 5631 AH 44, Eindhoven, The Netherlands. Fax 31-40-290-8621; e-mail r.m.lequin{at}planet.nl.


Abstract

This brief note addresses the historical background of the invention of the enzyme immunoassay (EIA) and enzyme-linked immunosorbent assay (ELISA). These assays were developed independently and simultaneously by the research group of Peter Perlmann and Eva Engvall at Stockholm University in Sweden and by the research group of Anton Schuurs and Bauke van Weemen in The Netherlands. Today, fully automated instruments in medical laboratories around the world use the immunoassay principle with an enzyme as the reporter label for routine measurements of innumerable analytes in patient samples. The impact of EIA/ELISA is reflected in the overwhelmingly large number of times it has appeared as a keyword in the literature since the 1970s. Clinicians and their patients, medical laboratories, in vitro diagnostics manufacturers, and worldwide healthcare systems owe much to these four inventors.




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The author of the article cited above responds:.
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S. Avrameas
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E. Engvall
Perspective on the Historical Note on EIA/ELISA by Dr. R.M. Lequin
Clin. Chem., December 1, 2005; 51(12): 2225 - 2225.
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B. K. van Weemen
The Rise of EIA/ELISA
Clin. Chem., December 1, 2005; 51(12): 2226 - 2226.
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